Evidence relating the inhibitory effect of cobalt on the activity of δ-aminolevulinate synthase to the intracellular concentration of porphyrins

Nili Schoenfeld, Yehudit Greenblat, Orit Epstein, Donald P. Tschudy, Abraham Atsmon

Research output: Contribution to journalArticlepeer-review

Abstract

This study shows that the inhibition of ALAS activity caused by cobalt is directly correlated with the intracellular porphyrin concentration, thus indicating that cobalt exerts its inhibitory effect on ALAS activity as a result of the formation of cobalt-protoporphyrin.

Original languageEnglish
Pages (from-to)2333-2337
Number of pages5
JournalBiochemical Pharmacology
Volume32
Issue number15
DOIs
StatePublished - 1 Aug 1983

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