Evidence for intracochlear impedance changes following ethacrynic acid administration

M. Himelfarb, J. Kroin, D. Strelioff

Research output: Contribution to journalArticlepeer-review


The effects of intra arterial 30, 40, and 50 mg/kg doses of ethacrynic acid upon cochlear function in guinea pigs were studied for periods of three to five hours. Cochlear potentials recorded in the first turn included the endocochlear potential, whole nerve response, cochlear microphonics, and summating potentials in scala media, scala tympania, and scala vestibuli. Evidence of organ of Corti damage at 50 mg/kg was found in addition to electrical impedance changes in the cochlear membranes at all dose levels.

Original languageEnglish
Pages (from-to)880-887
Number of pages8
JournalOtolaryngology - Head and Neck Surgery
Issue number6
StatePublished - 1979
Externally publishedYes


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