TY - JOUR
T1 - Evidence for intracochlear impedance changes following ethacrynic acid administration
AU - Himelfarb, M.
AU - Kroin, J.
AU - Strelioff, D.
PY - 1979
Y1 - 1979
N2 - The effects of intra arterial 30, 40, and 50 mg/kg doses of ethacrynic acid upon cochlear function in guinea pigs were studied for periods of three to five hours. Cochlear potentials recorded in the first turn included the endocochlear potential, whole nerve response, cochlear microphonics, and summating potentials in scala media, scala tympania, and scala vestibuli. Evidence of organ of Corti damage at 50 mg/kg was found in addition to electrical impedance changes in the cochlear membranes at all dose levels.
AB - The effects of intra arterial 30, 40, and 50 mg/kg doses of ethacrynic acid upon cochlear function in guinea pigs were studied for periods of three to five hours. Cochlear potentials recorded in the first turn included the endocochlear potential, whole nerve response, cochlear microphonics, and summating potentials in scala media, scala tympania, and scala vestibuli. Evidence of organ of Corti damage at 50 mg/kg was found in addition to electrical impedance changes in the cochlear membranes at all dose levels.
UR - http://www.scopus.com/inward/record.url?scp=0018682006&partnerID=8YFLogxK
U2 - 10.1177/019459987908700624
DO - 10.1177/019459987908700624
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AN - SCOPUS:0018682006
SN - 0194-5998
VL - 87
SP - 880
EP - 887
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 6
ER -
