Evidence for biological rhythm in spermatogenesis in the pubertal hamster (Mesocricetus auratus): A flow cytometric study

M. Vigodner, H. Lewy, L. M. Lewin, L. Shochat, R. Golan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The number of cells in the S-phase fraction of the cell cycle reflects proliferative activity. Using flow cytometry histograms and the Phoenix M+ cell cycle program, the percent of cells in the S-phase fraction was measured in single cell suspensions prepared from testes of hamsters of different ages. A cyclical pattern with a period of 9 days, superimposed on another rhythm with a 38 day period was observed (p < 0.01) during hamster maturation and it disappeared after the second spermatogenic wave, where the S phase values reached a plateau. It was concluded that maturing animals passed through a stage in which testicular biological rhythm was involved. Therefore it was concluded that it takes approximately two spermatogenic waves before the proliferation rate in the testis reached a steady state.

Original languageEnglish
Pages (from-to)1119-1126
Number of pages8
JournalLife Sciences
Volume74
Issue number9
DOIs
StatePublished - 16 Jan 2004

Funding

FundersFunder number
Mintz Lau fund
Chief Scientist Office
Ministry of Health, State of Israel

    Keywords

    • Golden hamster
    • Proliferation
    • S-phase
    • Spermatogonia

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