Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: Consensus report of an International Working Group

Marco Cicardi; Konrad Bork; Teresa Caballero; Timothy Craig; H. H. Li; Hilary Longhurst; Avner Reshef; Bruce Zuraw; Werner Aberer; Emel Aygören-Pürsün; Aleena Banerji; Janne Bjorkander; Isabelle Boccon-Gibod; Laurence Bouillet; France Grenoble; Maria Bova; Tom Bowen; Canada Calgary; Ferreira Manuel Branco; Anette Bygum; Teresa Caballero; Mauro Cancian; Maria Graça Castel-Branco; Caterina de Carolis; Enikö Mihály; Josè Fabiani; Henriette Farkas; Mark Gompels; Richard Gower; Adriane Groffik; Anete Grumach; Mar Guillarte; Erik Hack; Landeros Maria Hernandez; Allen Kaplan; Alicia Lara; Iris Leibovich; Henry Li; Bob Lock; William Lumry; Alejandro Malbran; Inmaculada Martinez-Saguer; Campos Matta; Marcus Maurer; Dumitru Moldovan; Vincenzo Montinaro; Sandra Nieto; Patrik Nordenfelt; Krystyna Obtulovicz; Roberto Perricone; Nieves Prior; Marc Riedl; Valle Rodrigues do; Chiara Savoca; Peter Spaeth; Petra Staubach-Renz; Marcin Stobiecki; Massimo Triggiani; Romualdo Vacchini; Lilian Varga; Andrea Zanichelli; Kian Zarchi; Sacha Zeerleder; Lorenza Zingale

doi:10.1111/j.1398-9995.2011.02751.x

Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: Consensus report of an International Working Group

Marco Cicardi^*, Konrad Bork, Teresa Caballero, Timothy Craig, H. H. Li, Hilary Longhurst, Avner Reshef, Bruce Zuraw, Werner Aberer, Emel Aygören-Pürsün, Aleena Banerji, Janne Bjorkander, Isabelle Boccon-Gibod, Laurence Bouillet, France Grenoble, Maria Bova, Tom Bowen, Canada Calgary, Ferreira Manuel Branco, Anette BygumTeresa Caballero, Mauro Cancian, Maria Graça Castel-Branco, Caterina de Carolis, Enikö Mihály, Josè Fabiani, Henriette Farkas, Mark Gompels, Richard Gower, Adriane Groffik, Anete Grumach, Mar Guillarte, Erik Hack, Landeros Maria Hernandez, Allen Kaplan, Alicia Lara, Iris Leibovich, Henry Li, Bob Lock, William Lumry, Alejandro Malbran, Inmaculada Martinez-Saguer, Campos Matta, Marcus Maurer, Dumitru Moldovan, Vincenzo Montinaro, Sandra Nieto, Patrik Nordenfelt, Krystyna Obtulovicz, Roberto Perricone, Nieves Prior, Marc Riedl, Valle Rodrigues do, Chiara Savoca, Peter Spaeth, Petra Staubach-Renz, Marcin Stobiecki, Massimo Triggiani, Romualdo Vacchini, Lilian Varga, Andrea Zanichelli, Kian Zarchi, Sacha Zeerleder, Lorenza Zingale

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

A ngioedema owing to hereditary deficiency of C1 inhibitor (HAE) is a rare, life-threatening, disabling disease. In the last 2 years, the results of well-designed and controlled trials with existing and new therapies for this condition have been published, and new treatments reached the market. Current guidelines for the treatment for HAE were released before the new trials and before the new treatments became available and were essentially based on observational studies and expert opinion. To provide evidence-based HAE treatment guidelines supported by the new studies, a conference was held in Gargnano del Garda, Italy, from September 26 to 29, 2010. The meeting hosted 58 experienced HAE expert physicians, representatives of pharmaceutical companies and representatives of HAE patients' associations. Here, we report the topics discussed during the meeting and evidence-based consensus about management approaches for HAE in adult/adolescent patients.

Original language	English
Pages (from-to)	147-157
Number of pages	11
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	67
Issue number	2
DOIs	https://doi.org/10.1111/j.1398-9995.2011.02751.x
State	Published - Feb 2012
Externally published	Yes

Keywords

C1 inhibitor
bradykinin receptor antagonist
consensus document
hereditary angioedema
kallikrein inhibitor

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10.1111/j.1398-9995.2011.02751.x

Cite this

Cicardi, M., Bork, K., Caballero, T., Craig, T., Li, H. H., Longhurst, H., Reshef, A., Zuraw, B., Aberer, W., Aygören-Pürsün, E., Banerji, A., Bjorkander, J., Boccon-Gibod, I., Bouillet, L., Grenoble, F., Bova, M., Bowen, T., Calgary, C., Branco, F. M., ... Zingale, L. (2012). Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: Consensus report of an International Working Group. Allergy: European Journal of Allergy and Clinical Immunology, 67(2), 147-157. https://doi.org/10.1111/j.1398-9995.2011.02751.x

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title = "Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: Consensus report of an International Working Group",

abstract = "A ngioedema owing to hereditary deficiency of C1 inhibitor (HAE) is a rare, life-threatening, disabling disease. In the last 2 years, the results of well-designed and controlled trials with existing and new therapies for this condition have been published, and new treatments reached the market. Current guidelines for the treatment for HAE were released before the new trials and before the new treatments became available and were essentially based on observational studies and expert opinion. To provide evidence-based HAE treatment guidelines supported by the new studies, a conference was held in Gargnano del Garda, Italy, from September 26 to 29, 2010. The meeting hosted 58 experienced HAE expert physicians, representatives of pharmaceutical companies and representatives of HAE patients' associations. Here, we report the topics discussed during the meeting and evidence-based consensus about management approaches for HAE in adult/adolescent patients.",

keywords = "C1 inhibitor, bradykinin receptor antagonist, consensus document, hereditary angioedema, kallikrein inhibitor",

author = "Marco Cicardi and Konrad Bork and Teresa Caballero and Timothy Craig and Li, {H. H.} and Hilary Longhurst and Avner Reshef and Bruce Zuraw and Werner Aberer and Emel Ayg{\"o}ren-P{\"u}rs{\"u}n and Aleena Banerji and Janne Bjorkander and Isabelle Boccon-Gibod and Laurence Bouillet and France Grenoble and Maria Bova and Tom Bowen and Canada Calgary and Branco, {Ferreira Manuel} and Anette Bygum and Teresa Caballero and Mauro Cancian and Castel-Branco, {Maria Gra{\c c}a} and {de Carolis}, Caterina and Enik{\"o} Mih{\'a}ly and Jos{\`e} Fabiani and Henriette Farkas and Mark Gompels and Richard Gower and Adriane Groffik and Anete Grumach and Mar Guillarte and Erik Hack and Hernandez, {Landeros Maria} and Allen Kaplan and Alicia Lara and Iris Leibovich and Henry Li and Bob Lock and William Lumry and Alejandro Malbran and Inmaculada Martinez-Saguer and Campos Matta and Marcus Maurer and Dumitru Moldovan and Vincenzo Montinaro and Sandra Nieto and Patrik Nordenfelt and Krystyna Obtulovicz and Roberto Perricone and Nieves Prior and Marc Riedl and {Rodrigues do}, Valle and Chiara Savoca and Peter Spaeth and Petra Staubach-Renz and Marcin Stobiecki and Massimo Triggiani and Romualdo Vacchini and Lilian Varga and Andrea Zanichelli and Kian Zarchi and Sacha Zeerleder and Lorenza Zingale",

year = "2012",

month = feb,

doi = "10.1111/j.1398-9995.2011.02751.x",

language = "אנגלית",

volume = "67",

pages = "147--157",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

issn = "0105-4538",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "2",

}

Cicardi, M, Bork, K, Caballero, T, Craig, T, Li, HH, Longhurst, H, Reshef, A, Zuraw, B, Aberer, W, Aygören-Pürsün, E, Banerji, A, Bjorkander, J, Boccon-Gibod, I, Bouillet, L, Grenoble, F, Bova, M, Bowen, T, Calgary, C, Branco, FM, Bygum, A, Caballero, T, Cancian, M, Castel-Branco, MG, de Carolis, C, Mihály, E, Fabiani, J, Farkas, H, Gompels, M, Gower, R, Groffik, A, Grumach, A, Guillarte, M, Hack, E, Hernandez, LM, Kaplan, A, Lara, A, Leibovich, I, Li, H, Lock, B, Lumry, W, Malbran, A, Martinez-Saguer, I, Matta, C, Maurer, M, Moldovan, D, Montinaro, V, Nieto, S, Nordenfelt, P, Obtulovicz, K, Perricone, R, Prior, N, Riedl, M, Rodrigues do, V, Savoca, C, Spaeth, P, Staubach-Renz, P, Stobiecki, M, Triggiani, M, Vacchini, R, Varga, L, Zanichelli, A, Zarchi, K, Zeerleder, S & Zingale, L 2012, 'Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: Consensus report of an International Working Group', Allergy: European Journal of Allergy and Clinical Immunology, vol. 67, no. 2, pp. 147-157. https://doi.org/10.1111/j.1398-9995.2011.02751.x

Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: Consensus report of an International Working Group. / Cicardi, Marco; Bork, Konrad; Caballero, Teresa et al.
In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 67, No. 2, 02.2012, p. 147-157.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency

T2 - Consensus report of an International Working Group

AU - Cicardi, Marco

AU - Bork, Konrad

AU - Caballero, Teresa

AU - Craig, Timothy

AU - Li, H. H.

AU - Longhurst, Hilary

AU - Reshef, Avner

AU - Zuraw, Bruce

AU - Aberer, Werner

AU - Aygören-Pürsün, Emel

AU - Banerji, Aleena

AU - Bjorkander, Janne

AU - Boccon-Gibod, Isabelle

AU - Bouillet, Laurence

AU - Grenoble, France

AU - Bova, Maria

AU - Bowen, Tom

AU - Calgary, Canada

AU - Branco, Ferreira Manuel

AU - Bygum, Anette

AU - Caballero, Teresa

AU - Cancian, Mauro

AU - Castel-Branco, Maria Graça

AU - de Carolis, Caterina

AU - Mihály, Enikö

AU - Fabiani, Josè

AU - Farkas, Henriette

AU - Gompels, Mark

AU - Gower, Richard

AU - Groffik, Adriane

AU - Grumach, Anete

AU - Guillarte, Mar

AU - Hack, Erik

AU - Hernandez, Landeros Maria

AU - Kaplan, Allen

AU - Lara, Alicia

AU - Leibovich, Iris

AU - Li, Henry

AU - Lock, Bob

AU - Lumry, William

AU - Malbran, Alejandro

AU - Martinez-Saguer, Inmaculada

AU - Matta, Campos

AU - Maurer, Marcus

AU - Moldovan, Dumitru

AU - Montinaro, Vincenzo

AU - Nieto, Sandra

AU - Nordenfelt, Patrik

AU - Obtulovicz, Krystyna

AU - Perricone, Roberto

AU - Prior, Nieves

AU - Riedl, Marc

AU - Rodrigues do, Valle

AU - Savoca, Chiara

AU - Spaeth, Peter

AU - Staubach-Renz, Petra

AU - Stobiecki, Marcin

AU - Triggiani, Massimo

AU - Vacchini, Romualdo

AU - Varga, Lilian

AU - Zanichelli, Andrea

AU - Zarchi, Kian

AU - Zeerleder, Sacha

AU - Zingale, Lorenza

PY - 2012/2

Y1 - 2012/2

N2 - A ngioedema owing to hereditary deficiency of C1 inhibitor (HAE) is a rare, life-threatening, disabling disease. In the last 2 years, the results of well-designed and controlled trials with existing and new therapies for this condition have been published, and new treatments reached the market. Current guidelines for the treatment for HAE were released before the new trials and before the new treatments became available and were essentially based on observational studies and expert opinion. To provide evidence-based HAE treatment guidelines supported by the new studies, a conference was held in Gargnano del Garda, Italy, from September 26 to 29, 2010. The meeting hosted 58 experienced HAE expert physicians, representatives of pharmaceutical companies and representatives of HAE patients' associations. Here, we report the topics discussed during the meeting and evidence-based consensus about management approaches for HAE in adult/adolescent patients.

AB - A ngioedema owing to hereditary deficiency of C1 inhibitor (HAE) is a rare, life-threatening, disabling disease. In the last 2 years, the results of well-designed and controlled trials with existing and new therapies for this condition have been published, and new treatments reached the market. Current guidelines for the treatment for HAE were released before the new trials and before the new treatments became available and were essentially based on observational studies and expert opinion. To provide evidence-based HAE treatment guidelines supported by the new studies, a conference was held in Gargnano del Garda, Italy, from September 26 to 29, 2010. The meeting hosted 58 experienced HAE expert physicians, representatives of pharmaceutical companies and representatives of HAE patients' associations. Here, we report the topics discussed during the meeting and evidence-based consensus about management approaches for HAE in adult/adolescent patients.

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KW - bradykinin receptor antagonist

KW - consensus document

KW - hereditary angioedema

KW - kallikrein inhibitor

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C2 - 22126399

AN - SCOPUS:84855779242

SN - 0105-4538

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EP - 157

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 2

ER -

Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: Consensus report of an International Working Group

Abstract

Keywords

Access to Document

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