Evaluation of the impact of vasa previa on feto-placental hormonal synthesis and fetal growth

Yaakov Melcer, Ron Maymon*, Marina Pekar-Zlotin, Orna Levinsohn-Tavor, Josef Tovbin, Eric Jauniaux

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Introduction A vasa previa (VP) refers to aberrant chorionic vessels which can either connect the chorionic plate to a velamentous cord (type I) or a succenturiate or accessory lobe to the main placental mass (type II). Methods We performed retrospective cohort study of 32 singleton pregnancies diagnosed with VP. The levels of maternal serum alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG) and unconjugated estriol (uE3) were measured at 15–18 weeks as part of the triple test screening for Trisomy 21. The data were subdivided according to the type of VP and compared with those of a control group with central cord insertion and no succenturiate or accessory placental lobe. Results Twenty one (65.6%) parturient women presented with VP type I and 11 (34.4%) with VP type II. The mean birthweight and placental weight was significantly higher in pregnancies with VP type II than in pregnancies with VP with VP type I (3037.3 ± 400.9 gr vs 2493.5 ± 491.6 gr; p = 0.004 and 511.0 ± 47.2 gr vs 367.1 ± 64.3 gr; p < 0.0001; respectively). The mean hCG level in VP type II was significantly (p < 0.001) higher than those with type I (2.38 MoM vs 1.17 MoM) and compared to controls (2.38 MoM vs 0.99 MoM). Conclusions There is no obvious impact on both placental and fetal growth in VP type II. By contrast, VP type I is associated with slower feto-placental growth secondary to impaired development and biological functions of the placenta during the first half of pregnancy.

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
StatePublished - Aug 2017


  • Birthweight
  • Prenatal
  • Serum markers
  • Triple test
  • Ultrasound
  • Vasa previa


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