TY - JOUR
T1 - Evaluation of the criti view in a pig model of abdominal aortic occlusion and graded hemorrhage
AU - Mayevsky, A.
AU - Preisman, S.
AU - Willenz, PE
AU - Castel, D.
AU - Perel, A.
AU - Givony, D.
AU - Dekel, N.
AU - Oren, L.
AU - Pewzner, E.
PY - 2009
Y1 - 2009
N2 - We hypothesize that in the presence of reduced oxygen delivery and extraction, blood flow will be redistributed in order to protect the most vital organs (e.g., brain and heart) by increasing their regional blood flow, while O 2 delivery to the less vital organs (e.g., GI tract or urethral wall) will diminish. Evaluation of mitochondrial function in vivo could be done by monitoring the oxidation reduction state of the respiratory chain. Thus, the NADH redox state of less vital organs could serve as an indicator of overall O 2 imbalance as well as an endpoint of resuscitation. We have therefore tested, in a pig model, a new medical device providing real time data on NADH redox state and tissue blood flow- TBF This device contains a modified three way Foley catheter with a fiber optic probe which connects the measurement unit to the tested tissue. Female pigs underwent graded hemorrhage (GH) or Aortic clamping (AC). The main effects of GH started when blood volume decreased by 30%. At 40% blood loss, minimal levels of TBF were correlated to the maximal NADH levels. The values of the 2 parameters returned to baseline after retransfusion of the shed blood. Aortic clamping led to significant decrease in TBF while NADH levels increased. After aortic declamping the parameters recovered to normal values. Due to the short length of the urethra in female pigs and the instable contact between the probe and the tissue, inconsistency of the responses was observed. Our preliminary results show that the Criti View may be a useful tool for the detection of body O 2 imbalance.
AB - We hypothesize that in the presence of reduced oxygen delivery and extraction, blood flow will be redistributed in order to protect the most vital organs (e.g., brain and heart) by increasing their regional blood flow, while O 2 delivery to the less vital organs (e.g., GI tract or urethral wall) will diminish. Evaluation of mitochondrial function in vivo could be done by monitoring the oxidation reduction state of the respiratory chain. Thus, the NADH redox state of less vital organs could serve as an indicator of overall O 2 imbalance as well as an endpoint of resuscitation. We have therefore tested, in a pig model, a new medical device providing real time data on NADH redox state and tissue blood flow- TBF This device contains a modified three way Foley catheter with a fiber optic probe which connects the measurement unit to the tested tissue. Female pigs underwent graded hemorrhage (GH) or Aortic clamping (AC). The main effects of GH started when blood volume decreased by 30%. At 40% blood loss, minimal levels of TBF were correlated to the maximal NADH levels. The values of the 2 parameters returned to baseline after retransfusion of the shed blood. Aortic clamping led to significant decrease in TBF while NADH levels increased. After aortic declamping the parameters recovered to normal values. Due to the short length of the urethra in female pigs and the instable contact between the probe and the tissue, inconsistency of the responses was observed. Our preliminary results show that the Criti View may be a useful tool for the detection of body O 2 imbalance.
KW - Hemoglobin oxygenation
KW - Microcirculatory blood flow
KW - Mitochondrial function
KW - NADH redox state
KW - Urethral wall vitality
UR - http://www.scopus.com/inward/record.url?scp=65149099772&partnerID=8YFLogxK
U2 - 10.1117/12.808690
DO - 10.1117/12.808690
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AN - SCOPUS:65149099772
SN - 1605-7422
VL - 7173
JO - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
JF - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
M1 - 71730L
T2 - Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications IX
Y2 - 24 January 2009 through 25 January 2009
ER -