Evaluation of the choroid in women with uncomplicated pregnancy

Li Su, Wongsiri Taweebanjongsin, Stephanie L. Gaw, Gilad Rabina, Srinivas R. Sadda, Irena Tsui*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: To study the choroid in uncomplicated pregnant women using advanced optical coherence tomography (OCT) imaging and analysis. Methods: Women with uncomplicated pregnancy in the third trimester (>28 weeks gestational age) and age-matched nonpregnant women were enrolled in this prospective study. All subjects underwent spectral-domain OCT with enhanced depth imaging mode and spectral-domain optical coherent tomography angiography (OCTA). Main outcomes were subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI), and choriocapillaris flow deficits (CC FD). Results: Twenty-two eyes of 12 uncomplicated pregnant women and 23 eyes of 15 nonpregnant, female controls were included. The mean age was 32.27 ± 6.96 years for the pregnant group and 30.08 ± 5.49 years for control group (P > 0.05). Mean SFCT was 238.70 ± 82.96 μm in the pregnant group, and 277.40 ± 61.79 μm in the control group. CVI was 67.58% ± 2.45% in the pregnant group and 67.31% ± 2.62% in the control group. The CC FD% was 54.06 ± 3.95 in the pregnant group, and 55.02 ± 3.78 in the control group. There was no significant difference between the pregnant and control groups (P > 0.05) in SFCT, CVI or CC FD. Conclusions: Although extensive hemodynamic changes occurred with pregnancy, choroidal measurements by OCT and OCTA demonstrated no differences in uncomplicated third-trimester pregnant women compared with nonpregnant controls. Translational Relevance: The unaltered choroid in uncomplicated third-trimester pregnancy we described allows clinicians to determine whether abnormal choroidal measurements could be used as a biomarker for complications of pregnancy.

Original languageEnglish
Article number24
Pages (from-to)1-8
Number of pages8
JournalTranslational Vision Science and Technology
Issue number9
StatePublished - 2020


FundersFunder number
Stein Eye Institute
National Institutes of HealthR21EY030 29501A1
Research to Prevent Blindness


    • Choriocapillaris
    • Choroidal vasculature index
    • Optical coherence tomography
    • Optical coherence tomography angiography
    • Pregnancy
    • Subfoveal choroidal thickness


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