Evaluation of sickle hemoglobin and desickling agents by falling ball viscometry

N. V. Paniker, I. Ben-Bassat, E. Beutler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A falling ball viscometer has been used to measure the increased viscosity of sickle hemoglobin solutions at varying degrees of deoxygenation. The viscosity of such solutions was found to decrease rapidly with storage. This change was hot due to methemoglobin formation or loss of a dialyzable or heat-stable cofactor. Viscosity of hemoglobin solutions was increased by 2,3-diphosphoglycerate, in inositolhexaphosphate, and pyridoxal phosphate. It was decreased by high concentrations of urea and lower concentrations of cyanate and carbamyl phosphate. Measurements carried out with a falling ball viscometer may be a useful technique for the evaluation of potential desickling agents.

Original languageEnglish
Pages (from-to)282-290
Number of pages9
JournalTranslational Research
Volume80
Issue number2
StatePublished - Aug 1972
Externally publishedYes

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