TY - JOUR
T1 - Evaluation of human chorionic gonadotropin stimulation tests in prepubertal and early pubertal boys
AU - Kauschansky, A.
AU - Frydman, M.
AU - Nussinovitch, M.
AU - Varsano, I.
PY - 1995/11
Y1 - 1995/11
N2 - Conclusion: Single hCG injection used as a screening test in the evaluation of hypogonadism is conclusive when positive. Only when the initial test is negative may a repeated test help establish the diagnosis. We evaluated the diagnostic significance of single versus repeated human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis in 25 boys (10 prepubertal group A; 15 early pubertal, group B) with suspected hypogonadism. All subjects received a single injection of hCG (5000 U/1.7 m2) and 1 month later, three repeated injections of 1500 U, one each on alternate days. In 19 out of the 25 boys, testosterone increased normally in both tests: from 20±6 to 156±82 ng/dl and from 107±105 to 615±293 ng/dl, following a single hCG injection, and from 30±19 to 439±298 ng/dl and from 94±55 to 826±272 ng/dl, following repeated injections in groups A and B, respectively. The difference between the tests was significant (P<0.01).
AB - Conclusion: Single hCG injection used as a screening test in the evaluation of hypogonadism is conclusive when positive. Only when the initial test is negative may a repeated test help establish the diagnosis. We evaluated the diagnostic significance of single versus repeated human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis in 25 boys (10 prepubertal group A; 15 early pubertal, group B) with suspected hypogonadism. All subjects received a single injection of hCG (5000 U/1.7 m2) and 1 month later, three repeated injections of 1500 U, one each on alternate days. In 19 out of the 25 boys, testosterone increased normally in both tests: from 20±6 to 156±82 ng/dl and from 107±105 to 615±293 ng/dl, following a single hCG injection, and from 30±19 to 439±298 ng/dl and from 94±55 to 826±272 ng/dl, following repeated injections in groups A and B, respectively. The difference between the tests was significant (P<0.01).
KW - Testicular function
KW - Testicular steroidogenesis
KW - hCG test
UR - http://www.scopus.com/inward/record.url?scp=0028806041&partnerID=8YFLogxK
U2 - 10.1007/BF01957499
DO - 10.1007/BF01957499
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AN - SCOPUS:0028806041
SN - 0340-6199
VL - 154
SP - 890
EP - 892
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 11
ER -