Evaluation of human chorionic gonadotropin stimulation tests in prepubertal and early pubertal boys

A. Kauschansky*, M. Frydman, M. Nussinovitch, I. Varsano

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Conclusion: Single hCG injection used as a screening test in the evaluation of hypogonadism is conclusive when positive. Only when the initial test is negative may a repeated test help establish the diagnosis. We evaluated the diagnostic significance of single versus repeated human chorionic gonadotropin (hCG) stimulation of testicular steroidogenesis in 25 boys (10 prepubertal group A; 15 early pubertal, group B) with suspected hypogonadism. All subjects received a single injection of hCG (5000 U/1.7 m2) and 1 month later, three repeated injections of 1500 U, one each on alternate days. In 19 out of the 25 boys, testosterone increased normally in both tests: from 20±6 to 156±82 ng/dl and from 107±105 to 615±293 ng/dl, following a single hCG injection, and from 30±19 to 439±298 ng/dl and from 94±55 to 826±272 ng/dl, following repeated injections in groups A and B, respectively. The difference between the tests was significant (P<0.01).

Original languageEnglish
Pages (from-to)890-892
Number of pages3
JournalEuropean Journal of Pediatrics
Volume154
Issue number11
DOIs
StatePublished - Nov 1995

Keywords

  • Testicular function
  • Testicular steroidogenesis
  • hCG test

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