Evaluation of dengue serological tests available in Puerto Rico for identification of prior dengue infection for prevaccination screening

Matthew Bonaparte, James Huleatt, Shekema Hodge, Lingyi Zheng, Yaniv Lustig, Carlos A. DiazGranados, Yasemin Ataman-Önal, Stephen Savarino

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed a dengue IgG rapid diagnostic test (RDT) and IgG enzyme-linked immunosorbent assay (ELISA) to determine their suitability for dengue prevaccination screening. Each exhibited ≥99% specificity. The RDT demonstrated no Zika cross-reactivity, while the ELISA displayed greater sensitivity. Both could safely guide vaccination in Puerto Rico pending availability of improved serotests.

Original languageEnglish
Article number114918
JournalDiagnostic Microbiology and Infectious Disease
Volume96
Issue number3
DOIs
StatePublished - Mar 2020
Externally publishedYes

Keywords

  • CYD-TDV
  • Cross-reactivity
  • Dengue serostatus
  • Dengvaxia
  • Flaviviruses
  • Prevaccination screening
  • Prior dengue infection
  • Sensitivity
  • Specificity

Fingerprint

Dive into the research topics of 'Evaluation of dengue serological tests available in Puerto Rico for identification of prior dengue infection for prevaccination screening'. Together they form a unique fingerprint.

Cite this