European registry on helicobacter pylori management (hp-eureg): First-line therapy in Israel

Doron Boltin, Zaza Beniashvili, Adi Lahat, Jonathan Hirsch, Olga P. Nyssen, Francis Megraud, Colm O'Morain, Javier P. Gisbert, Yaron Niv

Research output: Contribution to journalArticlepeer-review


Background: The antibiotic resistance profile of Helicobacter pylori (H. pylori) is constantly changing. Up-to-date and reliable data for the effectiveness of first-line H. pylori treatment protocols are necessary to provide evidence-based best-practice guidelines. Objectives: To determine the effectiveness, compliance and safety of first-line treatment for H. pylori in Israel. Methods: An observational, prospective, multicenter study was conducted in tertiary referral centers in Israel, as part of the European registry on H. pylori management (Hp-EuReg). H. pylori-\nfected patients were included from 2013 to March 2020. Data collected included demographics, clinical data, diagnostic tests, previous eradication attempts, current treatment, compliance, adverse events, and treatment outcome result. Results: In total, 242 patients were registered, including 121 (50%) who received first-line therapy, 41% of these individuals received clarithromycin based triple therapy and 58.9% received a four-drug regimen. The overall effectiveness of first-line therapy was 85% and 86% by modified intention-to-treat and per protocol analyses, respectively. The effectiveness of both sequential and concomitant therapies was 100% while clarithromycin-based triple therapy achieved an eradication rate of 79%. Treatment eradication was higher among patients who received high dose proton pump inhibitor (PPI) compared to those treated with low dose PPI (100% vs. 81.5% respectively, P< 0.01). No difference in treatment effectiveness was found between 7-, 10-, and 14-day treatment. Conclusions: The effectiveness of clarithromycin-based triple therapy is suboptimal. First-line treatment of H. pylori infection should consist of four drugs, including high dose PPI, according to international guidelines.

Original languageEnglish
Pages (from-to)38-42
Number of pages5
JournalIsrael Medical Association Journal
Issue number1
StatePublished - Jan 2021


  • Clarithromycin
  • Eradication
  • European registry on Helicobacter pylori management (Hp-EuReg)
  • Helicobacter pylori (H. pylori]


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