TY - JOUR
T1 - Ethnicity and familial factors in the etiology of acute appendicitis
AU - Shamis, Igor
AU - Livshits, Gregory
AU - Feldman, Uliana
PY - 1994
Y1 - 1994
N2 - The role of various socioeconomic, ethnic, and family factors in the development of acute appendicitis (AA) was studied in two generational groups totaling 2,331 individuals. Univariate analyses revealed that ethnicity, residence, family history, and education are associated with AA. However, only two, ethnicity and education, were retained following multiple forward, stepwise logistic regression. Caucasians, in contrast to Mongoloids and Uzbeks and those with high education showed significantly higher probabilities of undergoing an appendectomy. Odds ratios comparing Caucasians to Uzbeks and low education to high education were 1.6 and 0.7, respectively. Results confirm an association of higher AA frequency with higher socioeconomic status but do not explain the ethnic differences in the incidence of AA. Examination of aggregation of AA in 782 families indicates a familial factor in predisposition. Although this analysis suggests that genetic factors contribute significantly to the development of AA, only segregation analysis will allow more definitive conclusions. © 1994 Wiley‐Liss, Inc.
AB - The role of various socioeconomic, ethnic, and family factors in the development of acute appendicitis (AA) was studied in two generational groups totaling 2,331 individuals. Univariate analyses revealed that ethnicity, residence, family history, and education are associated with AA. However, only two, ethnicity and education, were retained following multiple forward, stepwise logistic regression. Caucasians, in contrast to Mongoloids and Uzbeks and those with high education showed significantly higher probabilities of undergoing an appendectomy. Odds ratios comparing Caucasians to Uzbeks and low education to high education were 1.6 and 0.7, respectively. Results confirm an association of higher AA frequency with higher socioeconomic status but do not explain the ethnic differences in the incidence of AA. Examination of aggregation of AA in 782 families indicates a familial factor in predisposition. Although this analysis suggests that genetic factors contribute significantly to the development of AA, only segregation analysis will allow more definitive conclusions. © 1994 Wiley‐Liss, Inc.
UR - http://www.scopus.com/inward/record.url?scp=84995262675&partnerID=8YFLogxK
U2 - 10.1002/ajhb.1310060310
DO - 10.1002/ajhb.1310060310
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AN - SCOPUS:84995262675
SN - 1042-0533
VL - 6
SP - 351
EP - 358
JO - American Journal of Human Biology
JF - American Journal of Human Biology
IS - 3
ER -