Ethnic groups and high sensitivity C-reactive protein in Israel

Ofir Wolach, Yaron Arbel, Michael Cohen, Uri Goldbourt, Uzi Rebhun, Itzhak Shapira, Shlomo Berliner, Ori Rogowski

Research output: Contribution to journalArticlepeer-review

Abstract

High-sensitivity C-reactive protein (hs-CRP) is a biomarker that correlates with atherothrombotic risk and outcome. hs-CRP is influenced by various modifiable and non-modifiable factors. We studied the relationship between ethnic background and hs-CRP level, among the Jewish population in Israel. A total of 3659 men and 2180 women were divided into two ethnic groups (Ashkenazi and Sephardic Jews), based on the knowledge of Jewish immigration patterns throughout the centuries. Mean hs-CRP levels were calculated for each group and were adjusted for various factors known to influence hs-CRP. Sephardic Jews were found to have higher adjusted mean hs-CRP levels (2.0 mg l-1 for men and 3.9 mg l-1 for women) compared with Ashkenazi Jews (1.5 mg l-1 for men and 2.9 mg l-1 for women). Ethnic background emerged as an independent significant predictor of hs-CRP levels. We demonstrated that ethnicity is an important factor when considering hs-CRP as a marker of atherothrombotic risk.

Original languageEnglish
Pages (from-to)296-306
Number of pages11
JournalBiomarkers
Volume13
Issue number3
DOIs
StatePublished - May 2008

Keywords

  • Ethnicity
  • Gender
  • High-sensitivity C-reactive protein
  • Jewish

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