Abstract
Ethanol enhances expression of cell surface class I major histocompatibility complex (MHC) antigens in a variety of cell lines; up to an eightfold increase is observed in an embryonic cell line. In ethanol-treated L cells, increased cell surface expression of MHC antigens occurs with a concomitant increase in steady-state RNA levels. This effect is promoter dependent and restricted, because not all gene products are elevated. The effective ethanol concentration (1%) is physiologically attainable, leading to speculations about the role of elevated MHC antigens in alcohol-related diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 469-473 |
| Number of pages | 5 |
| Journal | FASEB Journal |
| Volume | 1 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1987 |
| Externally published | Yes |