Ethanol: an enhancer of major histocompatibility complex antigen expression

L. J. Parent, R. Ehrlich, L. Matis, D. S. Singer

Research output: Contribution to journalArticlepeer-review


Ethanol enhances expression of cell surface class I major histocompatibility complex (MHC) antigens in a variety of cell lines; up to an eightfold increase is observed in an embryonic cell line. In ethanol-treated L cells, increased cell surface expression of MHC antigens occurs with a concomitant increase in steady-state RNA levels. This effect is promoter dependent and restricted, because not all gene products are elevated. The effective ethanol concentration (1%) is physiologically attainable, leading to speculations about the role of elevated MHC antigens in alcohol-related diseases.

Original languageEnglish
Pages (from-to)469-473
Number of pages5
JournalFASEB Journal
Issue number6
StatePublished - 1987
Externally publishedYes


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