Estrogen regulation of vasoactive intestinal peptide mRNA in rat hypothalamus

Illana Gozes; Haim Werner; Mahmoud Fawzi; Abdelsamad Abdelatty; Yael Shani; Mati Fridkin; Yitzhak Koch

doi:10.1007/BF02896857

Estrogen regulation of vasoactive intestinal peptide mRNA in rat hypothalamus

Illana Gozes^*, Haim Werner, Mahmoud Fawzi, Abdelsamad Abdelatty, Yael Shani, Mati Fridkin, Yitzhak Koch

^*Corresponding author for this work

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

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Abstract

The participation of gonadal steroid hormones in regulation of the vasoactive intestinal peptide (VIP) gene expression in the hypothalamus was studied using a quantitative densitometric hybridization assay. In the female rat the levels of VIP mRNA were found to be significantly decreased following ovariectomy (4.41 ± 0.7 arbitrary units of absorbance vs. 8.52 ± 0.18). This decrease was largely reversed after three days of treatment with estradiol dibenzoate. In contrast to the female rats, no significant change in VIP mRNA levels was observed in the male rats, following orchidectomy. These results suggest a sexual dimorphism with regard to the steroid regulation of hypothalamic VIP gene expression in the rat.

Original language	English
Pages (from-to)	55-61
Number of pages	7
Journal	Journal of Molecular Neuroscience
Volume	1
Issue number	1
DOIs	https://doi.org/10.1007/BF02896857
State	Published - Mar 1989
Externally published	Yes

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title = "Estrogen regulation of vasoactive intestinal peptide mRNA in rat hypothalamus",

abstract = "The participation of gonadal steroid hormones in regulation of the vasoactive intestinal peptide (VIP) gene expression in the hypothalamus was studied using a quantitative densitometric hybridization assay. In the female rat the levels of VIP mRNA were found to be significantly decreased following ovariectomy (4.41 ± 0.7 arbitrary units of absorbance vs. 8.52 ± 0.18). This decrease was largely reversed after three days of treatment with estradiol dibenzoate. In contrast to the female rats, no significant change in VIP mRNA levels was observed in the male rats, following orchidectomy. These results suggest a sexual dimorphism with regard to the steroid regulation of hypothalamic VIP gene expression in the rat.",

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AU - Gozes, Illana

AU - Werner, Haim

AU - Fawzi, Mahmoud

AU - Abdelatty, Abdelsamad

AU - Shani, Yael

AU - Fridkin, Mati

AU - Koch, Yitzhak

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AB - The participation of gonadal steroid hormones in regulation of the vasoactive intestinal peptide (VIP) gene expression in the hypothalamus was studied using a quantitative densitometric hybridization assay. In the female rat the levels of VIP mRNA were found to be significantly decreased following ovariectomy (4.41 ± 0.7 arbitrary units of absorbance vs. 8.52 ± 0.18). This decrease was largely reversed after three days of treatment with estradiol dibenzoate. In contrast to the female rats, no significant change in VIP mRNA levels was observed in the male rats, following orchidectomy. These results suggest a sexual dimorphism with regard to the steroid regulation of hypothalamic VIP gene expression in the rat.

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Estrogen regulation of vasoactive intestinal peptide mRNA in rat hypothalamus

Abstract

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