TY - JOUR
T1 - Estradiol valerate as a possible endocrine reproductive disruptor
T2 - evidence from an in vivo rat model
AU - Seidman, Daniel S.
AU - Itsekson, Alek
AU - Alesker, Michael
AU - Zolti, Mati
AU - Carp, Howard
AU - Wolman, Igal
PY - 2009/4
Y1 - 2009/4
N2 - We used an in vivo rat model to demonstrate that low-dose intradermal exposure to E2 valerate has an inverse effect on the female's estrus cycle pattern and can significantly reduce litter size. These results suggest that, under certain circumstances, environmental exposure to exogenous estrogens may play a role as an endocrine disruptor and adversely affect reproductive outcome.
AB - We used an in vivo rat model to demonstrate that low-dose intradermal exposure to E2 valerate has an inverse effect on the female's estrus cycle pattern and can significantly reduce litter size. These results suggest that, under certain circumstances, environmental exposure to exogenous estrogens may play a role as an endocrine disruptor and adversely affect reproductive outcome.
UR - http://www.scopus.com/inward/record.url?scp=63249089458&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2008.08.018
DO - 10.1016/j.fertnstert.2008.08.018
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C2 - 18973879
AN - SCOPUS:63249089458
SN - 0015-0282
VL - 91
SP - 1510
EP - 1512
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 4 SUPPL.
ER -