Estradiol valerate as a possible endocrine reproductive disruptor: evidence from an in vivo rat model

Daniel S. Seidman, Alek Itsekson, Michael Alesker, Mati Zolti, Howard Carp, Igal Wolman

Research output: Contribution to journalArticlepeer-review

Abstract

We used an in vivo rat model to demonstrate that low-dose intradermal exposure to E2 valerate has an inverse effect on the female's estrus cycle pattern and can significantly reduce litter size. These results suggest that, under certain circumstances, environmental exposure to exogenous estrogens may play a role as an endocrine disruptor and adversely affect reproductive outcome.

Original languageEnglish
Pages (from-to)1510-1512
Number of pages3
JournalFertility and Sterility
Volume91
Issue number4 SUPPL.
DOIs
StatePublished - Apr 2009

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