Estradiol modulates uterine 18 kDa translocator protein gene expression in uterus and kidney of rats

Caroline Mazurika, Leo Veenman, Ronit Weizman, Miri Bidder, Svetlana Leschiner, Idit Golani, Ilana Spanier, Gary Weisinger, Moshe Gavish

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the effect of ovariectomy, with and without estradiol treatment, on 18 kDa translocator protein (TSPO) gene expression and its binding density in the uterus and kidney of rats. Ovariectomy causes a significant decrease in uterine, but not renal TSPO binding density, while estradiol treatment of ovariectomized rats restored TSPO binding density in the uterus. These TSPO density levels did not correlate with steady state or new RNA transcription. Our in vivo study suggests that estradiol is responsible for the maintenance of uterine TSPO density via transcriptional mechanisms. Our in vivo study also suggests that in the kidney estradiol appears to operate via post-transcriptional mechanisms to maintain TSPO density.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume307
Issue number1-2
DOIs
StatePublished - 13 Aug 2009

Keywords

  • 18 kDa translocator protein
  • Estradiol
  • Gene expression
  • Kidney
  • PBR
  • Peripheral-type benzodiazepine receptor
  • TSPO
  • Uterus

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