Estradiol modulates uterine 18 kDa translocator protein gene expression in uterus and kidney of rats

Caroline Mazurika; Leo Veenman; Ronit Weizman; Miri Bidder; Svetlana Leschiner; Idit Golani; Ilana Spanier; Gary Weisinger; Moshe Gavish

doi:10.1016/j.mce.2009.04.001

Estradiol modulates uterine 18 kDa translocator protein gene expression in uterus and kidney of rats

Caroline Mazurika, Leo Veenman, Ronit Weizman, Miri Bidder, Svetlana Leschiner, Idit Golani, Ilana Spanier, Gary Weisinger, Moshe Gavish^*

^*Corresponding author for this work

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Abstract

We examined the effect of ovariectomy, with and without estradiol treatment, on 18 kDa translocator protein (TSPO) gene expression and its binding density in the uterus and kidney of rats. Ovariectomy causes a significant decrease in uterine, but not renal TSPO binding density, while estradiol treatment of ovariectomized rats restored TSPO binding density in the uterus. These TSPO density levels did not correlate with steady state or new RNA transcription. Our in vivo study suggests that estradiol is responsible for the maintenance of uterine TSPO density via transcriptional mechanisms. Our in vivo study also suggests that in the kidney estradiol appears to operate via post-transcriptional mechanisms to maintain TSPO density.

Original language	English
Pages (from-to)	43-49
Number of pages	7
Journal	Molecular and Cellular Endocrinology
Volume	307
Issue number	1-2
DOIs	https://doi.org/10.1016/j.mce.2009.04.001
State	Published - 13 Aug 2009

Keywords

18 kDa translocator protein
Estradiol
Gene expression
Kidney
PBR
Peripheral-type benzodiazepine receptor
TSPO
Uterus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mce.2009.04.001

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title = "Estradiol modulates uterine 18 kDa translocator protein gene expression in uterus and kidney of rats",

abstract = "We examined the effect of ovariectomy, with and without estradiol treatment, on 18 kDa translocator protein (TSPO) gene expression and its binding density in the uterus and kidney of rats. Ovariectomy causes a significant decrease in uterine, but not renal TSPO binding density, while estradiol treatment of ovariectomized rats restored TSPO binding density in the uterus. These TSPO density levels did not correlate with steady state or new RNA transcription. Our in vivo study suggests that estradiol is responsible for the maintenance of uterine TSPO density via transcriptional mechanisms. Our in vivo study also suggests that in the kidney estradiol appears to operate via post-transcriptional mechanisms to maintain TSPO density.",

keywords = "18 kDa translocator protein, Estradiol, Gene expression, Kidney, PBR, Peripheral-type benzodiazepine receptor, TSPO, Uterus",

author = "Caroline Mazurika and Leo Veenman and Ronit Weizman and Miri Bidder and Svetlana Leschiner and Idit Golani and Ilana Spanier and Gary Weisinger and Moshe Gavish",

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AU - Mazurika, Caroline

AU - Veenman, Leo

AU - Weizman, Ronit

AU - Bidder, Miri

AU - Leschiner, Svetlana

AU - Golani, Idit

AU - Spanier, Ilana

AU - Weisinger, Gary

AU - Gavish, Moshe

PY - 2009/8/13

Y1 - 2009/8/13

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AB - We examined the effect of ovariectomy, with and without estradiol treatment, on 18 kDa translocator protein (TSPO) gene expression and its binding density in the uterus and kidney of rats. Ovariectomy causes a significant decrease in uterine, but not renal TSPO binding density, while estradiol treatment of ovariectomized rats restored TSPO binding density in the uterus. These TSPO density levels did not correlate with steady state or new RNA transcription. Our in vivo study suggests that estradiol is responsible for the maintenance of uterine TSPO density via transcriptional mechanisms. Our in vivo study also suggests that in the kidney estradiol appears to operate via post-transcriptional mechanisms to maintain TSPO density.

KW - 18 kDa translocator protein

KW - Estradiol

KW - Gene expression

KW - Kidney

KW - PBR

KW - Peripheral-type benzodiazepine receptor

KW - TSPO

KW - Uterus

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ER -

Estradiol modulates uterine 18 kDa translocator protein gene expression in uterus and kidney of rats

Abstract

Keywords

UN SDGs

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