Establishment of the hematopoietic microenvironment in the marrow of matrix-induced endochondral bone

K. F. McCarthy; S. Wientroub; M. Hale; A. H. Reddi

Establishment of the hematopoietic microenvironment in the marrow of matrix-induced endochondral bone

K. F. McCarthy, S. Wientroub, M. Hale, A. H. Reddi

Research output: Contribution to journal › Article › peer-review

Abstract

Implantation of demineralized diaphyseal bone matrix (DBM) into subcutaneous sites in allogeneic Long-Evans rats results in new endochondral bone formation accompanied by hematopoietic bone marrow differentiation in the newly formed ossicles. In the present study, we investigated the relationship between the time of appearance of hematopoietic stem cells (CFU-S) and those of certain postulated elements of the hematopoietic microenvironment, i.e., fibroblast colony-forming cells (CFC-F), colony-stimulating factors (CSF), and collagen types.

Original language	English
Pages (from-to)	131-138
Number of pages	8
Journal	Experimental Hematology
Volume	12
Issue number	2
State	Published - 1984
Externally published	Yes

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title = "Establishment of the hematopoietic microenvironment in the marrow of matrix-induced endochondral bone",

abstract = "Implantation of demineralized diaphyseal bone matrix (DBM) into subcutaneous sites in allogeneic Long-Evans rats results in new endochondral bone formation accompanied by hematopoietic bone marrow differentiation in the newly formed ossicles. In the present study, we investigated the relationship between the time of appearance of hematopoietic stem cells (CFU-S) and those of certain postulated elements of the hematopoietic microenvironment, i.e., fibroblast colony-forming cells (CFC-F), colony-stimulating factors (CSF), and collagen types.",

author = "McCarthy, {K. F.} and S. Wientroub and M. Hale and Reddi, {A. H.}",

year = "1984",

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AU - McCarthy, K. F.

AU - Wientroub, S.

AU - Hale, M.

AU - Reddi, A. H.

PY - 1984

Y1 - 1984

N2 - Implantation of demineralized diaphyseal bone matrix (DBM) into subcutaneous sites in allogeneic Long-Evans rats results in new endochondral bone formation accompanied by hematopoietic bone marrow differentiation in the newly formed ossicles. In the present study, we investigated the relationship between the time of appearance of hematopoietic stem cells (CFU-S) and those of certain postulated elements of the hematopoietic microenvironment, i.e., fibroblast colony-forming cells (CFC-F), colony-stimulating factors (CSF), and collagen types.

AB - Implantation of demineralized diaphyseal bone matrix (DBM) into subcutaneous sites in allogeneic Long-Evans rats results in new endochondral bone formation accompanied by hematopoietic bone marrow differentiation in the newly formed ossicles. In the present study, we investigated the relationship between the time of appearance of hematopoietic stem cells (CFU-S) and those of certain postulated elements of the hematopoietic microenvironment, i.e., fibroblast colony-forming cells (CFC-F), colony-stimulating factors (CSF), and collagen types.

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JO - Experimental Hematology

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SN - 0301-472X

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Establishment of the hematopoietic microenvironment in the marrow of matrix-induced endochondral bone

Abstract

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