Establishment of a human T-acute lymphoblastic leukemia cell line with a (16;20) chromosome translocation

Hannah Ben-Bassat; Zipora Shlomai; Gertrude Kohn; Miron Prokocimer

doi:10.1016/0165-4608(90)90148-4

Establishment of a human T-acute lymphoblastic leukemia cell line with a (16;20) chromosome translocation

Hannah Ben-Bassat^*
, Zipora Shlomai
, Gertrude Kohn
, Miron Prokocimer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A new T-cell line. Loucy, was established from the peripheral blood of a patient with T-cell acute lymphoblastic leukemia (T-ALL). The surface marker analysis of the cell line is OKT3+, OKT4+, THB4+, J5±, OKT6-, TdT-, and HLA-DR-. indicating stage IV in T-cell lineage. Karyotype analysis revealed 45,X.5q-,t(16;20)(p12;q13). The translocation between chromosomes 16 and 20 has not been previously detected in ALL. This cell line may be of value in evaluating the role of t(16;20) in the etiology of T-ALL.

Original language	English
Pages (from-to)	241-248
Number of pages	8
Journal	Cancer Genetics and Cytogenetics
Volume	49
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(90)90148-4
State	Published - 15 Oct 1990
Externally published	Yes

Funding

Funders
MJF Foundation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/0165-4608(90)90148-4

Cite this

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title = "Establishment of a human T-acute lymphoblastic leukemia cell line with a (16;20) chromosome translocation",

abstract = "A new T-cell line. Loucy, was established from the peripheral blood of a patient with T-cell acute lymphoblastic leukemia (T-ALL). The surface marker analysis of the cell line is OKT3+, OKT4+, THB4+, J5±, OKT6-, TdT-, and HLA-DR-. indicating stage IV in T-cell lineage. Karyotype analysis revealed 45,X.5q-,t(16;20)(p12;q13). The translocation between chromosomes 16 and 20 has not been previously detected in ALL. This cell line may be of value in evaluating the role of t(16;20) in the etiology of T-ALL.",

author = "Hannah Ben-Bassat and Zipora Shlomai and Gertrude Kohn and Miron Prokocimer",

note = "Funding Information: This work was supported in part by the MJF Foundation and the Paul Erhlich Center for the Study of Normal and Leukemic White Blood Cells.",

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doi = "10.1016/0165-4608(90)90148-4",

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AU - Ben-Bassat, Hannah

AU - Shlomai, Zipora

AU - Kohn, Gertrude

AU - Prokocimer, Miron

N1 - Funding Information: This work was supported in part by the MJF Foundation and the Paul Erhlich Center for the Study of Normal and Leukemic White Blood Cells.

PY - 1990/10/15

Y1 - 1990/10/15

N2 - A new T-cell line. Loucy, was established from the peripheral blood of a patient with T-cell acute lymphoblastic leukemia (T-ALL). The surface marker analysis of the cell line is OKT3+, OKT4+, THB4+, J5±, OKT6-, TdT-, and HLA-DR-. indicating stage IV in T-cell lineage. Karyotype analysis revealed 45,X.5q-,t(16;20)(p12;q13). The translocation between chromosomes 16 and 20 has not been previously detected in ALL. This cell line may be of value in evaluating the role of t(16;20) in the etiology of T-ALL.

AB - A new T-cell line. Loucy, was established from the peripheral blood of a patient with T-cell acute lymphoblastic leukemia (T-ALL). The surface marker analysis of the cell line is OKT3+, OKT4+, THB4+, J5±, OKT6-, TdT-, and HLA-DR-. indicating stage IV in T-cell lineage. Karyotype analysis revealed 45,X.5q-,t(16;20)(p12;q13). The translocation between chromosomes 16 and 20 has not been previously detected in ALL. This cell line may be of value in evaluating the role of t(16;20) in the etiology of T-ALL.

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ER -

Establishment of a human T-acute lymphoblastic leukemia cell line with a (16;20) chromosome translocation

Abstract

Funding

UN SDGs

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