Establishment of a human T-acute lymphoblastic leukemia cell line with a (16;20) chromosome translocation

Hannah Ben-Bassat, Zipora Shlomai, Gertrude Kohn, Miron Prokocimer

Research output: Contribution to journalArticlepeer-review

Abstract

A new T-cell line. Loucy, was established from the peripheral blood of a patient with T-cell acute lymphoblastic leukemia (T-ALL). The surface marker analysis of the cell line is OKT3+, OKT4+, THB4+, J5±, OKT6-, TdT-, and HLA-DR-. indicating stage IV in T-cell lineage. Karyotype analysis revealed 45,X.5q-,t(16;20)(p12;q13). The translocation between chromosomes 16 and 20 has not been previously detected in ALL. This cell line may be of value in evaluating the role of t(16;20) in the etiology of T-ALL.

Original languageEnglish
Pages (from-to)241-248
Number of pages8
JournalCancer Genetics and Cytogenetics
Volume49
Issue number2
DOIs
StatePublished - 15 Oct 1990
Externally publishedYes

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