Establishment and characterization of a cell line derived from human colon adenocarcinoma (Huccl-14)

A. Yaniv; Z. Altboum; A. Gazit; N. Bloch-Shtacher; H. Eylan

doi:10.1159/000162897

Establishment and characterization of a cell line derived from human colon adenocarcinoma (Huccl-14)

A. Yaniv^*, Z. Altboum, A. Gazit, N. Bloch-Shtacher, H. Eylan

^*Corresponding author for this work

Clinical Microbiology and Immunology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A continuous human colon carcinoma cell line (HuCCL-14) was established whose cells possess an epithelial-like morphology and are capable of growing in soft agar and on monolayers of normal cells. HuCCL-14 cells yielded high levels of carcinoembryonic antigen, and the analysis of their chromosomal constitution revealed a mode of 70 chromosomes per cell. HuCCL-14 cells produce malignant tumors when injected into nude mice. Preliminary virologic studies indicate the release of RNA particles having a density of K15-1.19 g/ml.

Original language	English
Pages (from-to)	220-230
Number of pages	11
Journal	Pathobiology
Volume	46
Issue number	4
DOIs	https://doi.org/10.1159/000162897
State	Published - 1978

Keywords

CEA
Cell line
Colon carcinoma
Karyotype
Malignancy
RNA particles

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000162897

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abstract = "A continuous human colon carcinoma cell line (HuCCL-14) was established whose cells possess an epithelial-like morphology and are capable of growing in soft agar and on monolayers of normal cells. HuCCL-14 cells yielded high levels of carcinoembryonic antigen, and the analysis of their chromosomal constitution revealed a mode of 70 chromosomes per cell. HuCCL-14 cells produce malignant tumors when injected into nude mice. Preliminary virologic studies indicate the release of RNA particles having a density of K15-1.19 g/ml.",

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AU - Altboum, Z.

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AU - Bloch-Shtacher, N.

AU - Eylan, H.

PY - 1978

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AB - A continuous human colon carcinoma cell line (HuCCL-14) was established whose cells possess an epithelial-like morphology and are capable of growing in soft agar and on monolayers of normal cells. HuCCL-14 cells yielded high levels of carcinoembryonic antigen, and the analysis of their chromosomal constitution revealed a mode of 70 chromosomes per cell. HuCCL-14 cells produce malignant tumors when injected into nude mice. Preliminary virologic studies indicate the release of RNA particles having a density of K15-1.19 g/ml.

KW - CEA

KW - Cell line

KW - Colon carcinoma

KW - Karyotype

KW - Malignancy

KW - RNA particles

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JO - Pathobiology

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Establishment and characterization of a cell line derived from human colon adenocarcinoma (Huccl-14)

Abstract

Keywords

UN SDGs

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