Essential fatty acid preparation improves biochemical and cognitive functions in experimental allergic encephalomyelitis rats

Shlomo Yehuda, Sharon Rabinovitz, David I. Mostofsky, Moshe Huberman, Benjamin Sredni

Research output: Contribution to journalArticlepeer-review

Abstract

This study examined the possible effects of a novel mixture of fatty acids, SR-3 (a specific ratio of a-linolenic acids), on brain biochemistry and on learning deficits induced by injection of an agent that induces experimental allergic encephalomyelitis. Treatment with SR-3 caused a decrease in myelin and changes in the fatty acid profile of brain synaptosomes, and a learning deficit. Eighteen days of treatment with SR-3 reversed the biochemical and learning deficit significantly, but did not restore them to normal levels. We propose that, most probably, the main action of SR-3 is the modulation of the cholesterol level, which in turn causes the modulation of the fatty acid profile and enhances learning by allowing improved neuronal communication.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalEuropean Journal of Pharmacology
Volume328
Issue number1
DOIs
StatePublished - Sep 1997
Externally publishedYes

Keywords

  • Experimental allergic encephalomyelitis
  • Fatty acid
  • Linolenic acid
  • Multiple sclerosis
  • α-Linolenic acid

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