Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis

Lucas R. Hoffman*, Christopher E. Pope, Hillary S. Hayden, Sonya Heltshe, Roie Levy, Sharon McNamara, Michael A. Jacobs, Laurence Rohmer, Matthew Radey, Bonnie W. Ramsey, Mitchell J. Brittnacher, Elhanan Borenstein, Samuel I. Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.

Original languageEnglish
Pages (from-to)396-399
Number of pages4
JournalClinical Infectious Diseases
Volume58
Issue number3
DOIs
StatePublished - Feb 2014
Externally publishedYes

Funding

FundersFunder number
National Institutes of HealthP30 DK089507
National Heart, Lung, and Blood InstituteK02HL105543

    Keywords

    • Escherichia coli
    • cystic fibrosis
    • inflammation
    • malabsorption
    • microbiota

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