Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis

Lucas R. Hoffman, Christopher E. Pope, Hillary S. Hayden, Sonya Heltshe, Roie Levy, Sharon McNamara, Michael A. Jacobs, Laurence Rohmer, Matthew Radey, Bonnie W. Ramsey, Mitchell J. Brittnacher, Elhanan Borenstein, Samuel I. Miller

Research output: Contribution to journalArticlepeer-review

Abstract

Cystic fibrosis gastrointestinal disease includes nutrient malabsorption and intestinal inflammation. We show that the abundances of Escherichia coli in fecal microbiota were significantly higher in young children with cystic fibrosis than in controls and correlated with fecal measures of nutrient malabsorption and inflammation, suggesting that E. coli could contribute to cystic fibrosis gastrointestinal dysfunction.

Original languageEnglish
Pages (from-to)396-399
Number of pages4
JournalClinical Infectious Diseases
Volume58
Issue number3
DOIs
StatePublished - Feb 2014
Externally publishedYes

Keywords

  • Escherichia coli
  • cystic fibrosis
  • inflammation
  • malabsorption
  • microbiota

Fingerprint

Dive into the research topics of 'Escherichia coli dysbiosis correlates with gastrointestinal dysfunction in children with cystic fibrosis'. Together they form a unique fingerprint.

Cite this