TY - JOUR
T1 - Escape phenomenon of low-density lipoprotein cholesterol during lovastatin treatment
AU - Rubinstein, Ardon
AU - Weintraub, Moshe
N1 - Funding Information:
From the Division of Cordiol University of South Alabama College of Medicine, Mobile, A7f0o ma. This report was supported in part by o grant from DuPont Merck Pharmaceutical Company, Wilmington, Delaware. Dr. Alpert’s address is. Divisron of Cardiology, Suite 1 OC, University of South Alabama Medical Center, 245 1 FilC ingrm Street, Mobile, Alabama 366 17. Manuscript received December 27, 1994; revised manuscript received and accepted Murch 17. 1995.
PY - 1995/7/15
Y1 - 1995/7/15
N2 - The main issue is whether briefly stopping treatment of the hypercholesterolemic patient will accelerate the atherosclerotic process. This is possible, but such a strategy is preferable only in a subgroup of patients who cannot tolerate cholestyramine, and in those who cannot bear the economic burden of increasing the dosage of statins. In addition, stopping and restarting the drug at different stages lessens the likelihood of more adverse effects occurring when the dosage is increased.
AB - The main issue is whether briefly stopping treatment of the hypercholesterolemic patient will accelerate the atherosclerotic process. This is possible, but such a strategy is preferable only in a subgroup of patients who cannot tolerate cholestyramine, and in those who cannot bear the economic burden of increasing the dosage of statins. In addition, stopping and restarting the drug at different stages lessens the likelihood of more adverse effects occurring when the dosage is increased.
UR - http://www.scopus.com/inward/record.url?scp=0029019470&partnerID=8YFLogxK
U2 - 10.1016/S0002-9149(99)80057-5
DO - 10.1016/S0002-9149(99)80057-5
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AN - SCOPUS:0029019470
SN - 0002-9149
VL - 76
SP - 184
EP - 186
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 3
ER -