Erythropoietin-producing hepatocellular receptor B6 is highly expressed in non-functioning pituitary neuroendocrine tumors and its expression correlates with tumor size

Hadara Rubinfeld, Zvi R. Cohen, Uzi Bendavid, Suzana Fichman-Horn, Adva Levy-Barda, Cfir David, Philippa Melamed, Ilan Shimon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Erythropoietin-producing hepatocellular (EPH) receptors are the largest known family of receptor tyrosine kinases characterized in humans. These proteins are involved in tissue organization, synaptic plasticity, vascular development and the progression of various diseases including cancer. The Erythropoietin-producing hepatocellular receptor tyrosine kinase member EphB6 is a pseudokinase which has not attracted an equivalent amount of interest as its enzymatically-active counterparts. The aim of this study was to assess the expression of EphB6 in pituitary tumors. Methods and Results: Human normal pituitaries and pituitary tumors were examined for EphB6 mRNA expression using real-time PCR and for EphB6 protein by immunohistochemistry and Western blotting. EphB6 was highly expressed in non-functioning pituitary neuroendocrine tumors (NF-PitNETs) versus the normal pituitary and GH-secreting PitNETs. EphB6 mRNA expression was correlated with tumor size. Conclusions: Our results suggest EphB6 aberrant expression in NF-PitNETs. Future studies are warranted to determine the role and significance of EphB6 in NF-PitNETs tumorigenesis.

Original languageEnglish
Article number297
JournalMolecular Biology Reports
Volume51
Issue number1
DOIs
StatePublished - Dec 2024

Funding

FundersFunder number
Fingerhot Karol and Lionora Foundation
Faculty of Medicine, American University of Beirut
Tel Aviv University0601253951

    Keywords

    • EphB6
    • Ephrins
    • NF-PitNETs
    • Pituitary
    • RTK

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