@article{a462c9cfbeb64676aacb6b036b6a9aea,
title = "Erythrocyte aggregation as a cause of slow flow in patients of acute coronary syndromes",
abstract = "Background: There are multiple lines of evidence to suggest the role of erythrocyte aggregation (EA) in microcirculatory dysfunction during conditions of very slow flow. Such conditions might develop in the myocardium of patients with acute coronary syndromes (ACS). Methods: EA as a function of shear stress was evaluated by using a cell flow properties analyzer (CFA) in a cohort of 91 ACS patients and in 36 patients with non specific chest pain or heart failure at the time of cardiac catheterization. Results: The ACS group included 34 patients with acute myocardial infarction and 57 patients with unstable angina. In addition, we examined 36 patients who underwent angiography for non specific chest pain or heart failure. A significant (r = 0.44, p < 0.0005) correlation was found between the concentration of fibrinogen and the average aggregate size (AAS) only when using conditions of very slow flow and applying relatively low (0.15 dyn/cm2) shear stress in the ACS group. This correlation decreased and became insignificant when applying shear stress forces of 1 dyn/cm2 and more. This correlation was nonsignificant for all the 5 shear stress forces (between 0.15 and 4 dyn/cm2) in the samples obtained from the non-ACS group. Conclusion: Erythrocytes that are suspended in autologous plasma obtained from patients with ACS tend to aggregate in conditions of very slow flow. These findings might be detrimental in terms of microcirculatory flow in ACS patients and might open new therapeutic options such as the use of low dose thrombolysis following PCI.",
keywords = "Fibrinogen, Inflammation, Red blood aggregation, Slow flow",
author = "Yaron Arbel and Shmuel Banai and Jessia Benhorin and Ariel Finkelstein and Itzhak Herz and Amir Halkin and Gad Keren and Saul Yedgar and Gershon Barashtein and Shlomo Berliner",
note = "Funding Information: This work was supported by grants from the US National Blood Foundation (American Association of Blood Banking, to SY and GB), the Israel Ministry of Health (to SY), and the Walter and Greta Stiel Chair for Heart Studies (SY). The authors thank Mrs. O. Fredman and Mrs. S. Levi for technical assistance. The authors of this manuscript have certified that they comply with the Principles of Ethical Publishing in the International Journal of Cardiology [34] .",
year = "2012",
month = feb,
day = "9",
doi = "10.1016/j.ijcard.2011.06.116",
language = "אנגלית",
volume = "154",
pages = "322--327",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "3",
}