Erratic G → A hypermutation within a complete caprine arthritis- encephalitis virus (CAEV) provirus

Simon Wain-Hobson; Pierre Sonigo; Mireille Guyader; Arona Gazit; Michel Henry

doi:10.1006/viro.1995.1261

Erratic G → A hypermutation within a complete caprine arthritis- encephalitis virus (CAEV) provirus

Simon Wain-Hobson^*, Pierre Sonigo, Mireille Guyader, Arona Gazit, Michel Henry

^*Corresponding author for this work

Clinical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

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Abstract

The complete nucleotide sequence of an integrated provirus of caprine arthritis-encephalitis virus (CAEV) has been determined. The provirus was defective due to extensive G → A hypermutation. Rather than being 8 smooth phenomenon distributed throughout the genome it was highly erratic with hypermutated and normal regions being juxtaposed, probably reflecting local fluctuations in the intracellular dCTP pool during reverse transcription of the CAEV genome. The pattern of sequence variation within the surface glycoproteins differs subtly from that of the primate lentiviruses.

Original language	English
Article number	71261
Pages (from-to)	297-303
Number of pages	7
Journal	Virology
Volume	209
Issue number	2
DOIs	https://doi.org/10.1006/viro.1995.1261
State	Published - 1 Jun 1995

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10.1006/viro.1995.1261

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Erratic G → A hypermutation within a complete caprine arthritis- encephalitis virus (CAEV) provirus

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