Erratic G → A hypermutation within a complete caprine arthritis- encephalitis virus (CAEV) provirus

Simon Wain-Hobson, Pierre Sonigo, Mireille Guyader, Arona Gazit, Michel Henry

Research output: Contribution to journalArticlepeer-review

Abstract

The complete nucleotide sequence of an integrated provirus of caprine arthritis-encephalitis virus (CAEV) has been determined. The provirus was defective due to extensive G → A hypermutation. Rather than being 8 smooth phenomenon distributed throughout the genome it was highly erratic with hypermutated and normal regions being juxtaposed, probably reflecting local fluctuations in the intracellular dCTP pool during reverse transcription of the CAEV genome. The pattern of sequence variation within the surface glycoproteins differs subtly from that of the primate lentiviruses.

Original languageEnglish
Article number71261
Pages (from-to)297-303
Number of pages7
JournalVirology
Volume209
Issue number2
DOIs
StatePublished - 1 Jun 1995

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