Ergebnisse eines prospektiven Multizentervergleichs der 2.Kolonkapselgeneration mit der Koloskopie

Translated title of the contribution: Prospective multicenter performance evaluation of the second-generation colon capsule compared with colonoscopy

R. Eliakim, K. Yassin, Y. Niv, Y. Metzger, J. Lachter, E. Ga, B. Sapoznikov, F. Konikoff, G. Leichtmann, Z. Fireman, Y. Kopelman, S. N. Adler, H. J. Schulz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background and study aims:A second-generation capsule endoscopy system, using the PillCam Colon2, was developed to increase sensitivity for colorectal polyp detection compared with the first-generation system. The performance of this new system is reported. Patients and methods:In a five-center feasibility study, second-generation capsule endoscopy was prospectively compared with conventional colonoscopy as gold standard for the detection of colo rectal polyps and other colonic disease, in a cohort of patients scheduled for colonoscopy and having known or suspected colonic disease. Colonoscopy was independently performed within 10hours after capsule ingestion. Capsule-positive but colonoscopy-negative cases were counted as false-positive. Results:104patients (mean age 49.8years) were enrolled; data from 98were analyzed. Patient rate for polyps of any size was 44%, 53% of these patients having adenomas. No adverse events related to either procedure were reported. The capsule sensitivity for the detection of patients with polyps 6mm was 89% (95% confidence interval CI 7097) and for those with polyps 10mm it was 88% (95% CI 5698), with speci ficities of 76% (95% CI 7278) and 89% (95% CI 8690), respectively. Both polyps missed by colonoscopy and mismatch in polyp size by study definition lowered specificity. Overall colon cleanliness for capsule endoscopy was adequate in 78% of patients (95% CI 6886). Conclusions:The new second-generation colon capsule endoscopy is a safe and effective method for visualizing the colon and detecting colonic lesions. Sensitivity and specificity for detecting colorectal polyps appear to be very good, sug gest ing a potential for improved accuracy compared with the first-generation system. Further pro spec tive and comparative studies are needed.

Translated title of the contributionProspective multicenter performance evaluation of the second-generation colon capsule compared with colonoscopy
Original languageGerman
Pages (from-to)144-149
Number of pages6
JournalEndoskopie Heute
Volume23
Issue number2
DOIs
StatePublished - 2010
Externally publishedYes

Keywords

  • colon capsule 2generation
  • colon video capsule endoscopy
  • colonoscopy
  • colorectal polyps

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