Equithesin: A hibernation-inducing drug?

Ruth Batzri-Izraeli, Zvi Wollberg, Razi Dmi'el

Research output: Contribution to journalArticlepeer-review

Abstract

1. Hibernating insectivore species (hedgehogs) and non-hibernating rodents (guinea pig and rat) were anaesthetized with 'equithesin' (a mixture of chloral hydrate, magnesium sulphate, and pentobarbitone sodium). 2. The physiological responses shown by the hedgehogs were similar to those observed in hedgehogs during a natural or cold-induced hibernation. 3. These responses included a strong reduction in body temperature, heart rate, respiration and oxygen consumption, and brain activity. 4. Such responses to equithesin were not observed in the non-hibemating rodent species. 5. These results suggest that equithesin is a potential tool for hibernation research.

Original languageEnglish
Pages (from-to)273-275
Number of pages3
JournalComparative biochemistry and physiology. C: Comparative pharmacology
Volume103
Issue number2
DOIs
StatePublished - Oct 1992

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