TY - JOUR
T1 - Equithesin
T2 - A hibernation-inducing drug?
AU - Batzri-Izraeli, Ruth
AU - Wollberg, Zvi
AU - Dmi'el, Razi
PY - 1992/10
Y1 - 1992/10
N2 - 1. Hibernating insectivore species (hedgehogs) and non-hibernating rodents (guinea pig and rat) were anaesthetized with 'equithesin' (a mixture of chloral hydrate, magnesium sulphate, and pentobarbitone sodium). 2. The physiological responses shown by the hedgehogs were similar to those observed in hedgehogs during a natural or cold-induced hibernation. 3. These responses included a strong reduction in body temperature, heart rate, respiration and oxygen consumption, and brain activity. 4. Such responses to equithesin were not observed in the non-hibemating rodent species. 5. These results suggest that equithesin is a potential tool for hibernation research.
AB - 1. Hibernating insectivore species (hedgehogs) and non-hibernating rodents (guinea pig and rat) were anaesthetized with 'equithesin' (a mixture of chloral hydrate, magnesium sulphate, and pentobarbitone sodium). 2. The physiological responses shown by the hedgehogs were similar to those observed in hedgehogs during a natural or cold-induced hibernation. 3. These responses included a strong reduction in body temperature, heart rate, respiration and oxygen consumption, and brain activity. 4. Such responses to equithesin were not observed in the non-hibemating rodent species. 5. These results suggest that equithesin is a potential tool for hibernation research.
UR - http://www.scopus.com/inward/record.url?scp=0026489396&partnerID=8YFLogxK
U2 - 10.1016/0742-8413(92)90007-T
DO - 10.1016/0742-8413(92)90007-T
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AN - SCOPUS:0026489396
SN - 0306-4492
VL - 103
SP - 273
EP - 275
JO - Comparative biochemistry and physiology. C: Comparative pharmacology
JF - Comparative biochemistry and physiology. C: Comparative pharmacology
IS - 2
ER -