Eppur Si Muove: ferritin is essential in modulating inflammation

K. Sharif, V. Vieira Borba, G. Zandman-Goddard, Y. Shoenfeld*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

31 Scopus citations

Abstract

Ferritin, which was only discovered in the last century, has stirred a formidable debate. Ferritin has long been appreciated as a non-specific acute-phase reactant. Several years ago, we hypothesized the contributory role of ferritin as a pathogenic molecule rather than being a product of inflammation. The latest emerging evidence provides support to this notion. Such revelation provides a step forward towards the understanding of disease conditions associated with hyperferritinaemia, and hence provide new targets for treatment modalities.

Original languageEnglish
Pages (from-to)149-150
Number of pages2
JournalClinical and Experimental Immunology
Volume191
Issue number2
DOIs
StatePublished - 2018

Keywords

  • acute phase reactant
  • ferritin
  • hyperferritenemic syndrome
  • macrophage activating syndrome
  • pro-inflammation

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