Eplerenone for chronic central serous chorioretinopathy–a randomized controlled prospective study

Roy Schwartz*, Zohar Habot-Wilner, Michael R. Martinez, Amir Nutman, Dafna Goldenberg, Shai Cohen, Shiri Shulman, Hanan Guzner-Gur, Anat Loewenstein, Michaella Goldstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Purpose: To evaluate the efficacy and safety of eplerenone for chronic nonresolving central serous chorioretinopathy (CSC). Methods: Prospective, double-blind, randomized placebo-controlled study. Nineteen eyes of 17 patients with persistent subretinal fluid (SRF) due to CSC were enrolled and randomized to receive eplerenone 50 mg/day or placebo for 3 months, followed by a 3-month follow-up. The main outcome measure was change in SRF from baseline to 3 months of treatment. Secondary outcomes included change in SRF at any time-point, complete resolution of SRF, improvement in choroidal thickness and change in best-corrected visual acuity (BCVA). Results: Thirteen eyes were treated with eplerenone and six with placebo. Both groups showed reduction in SRF throughout the treatment period, with a significant reduction at months 1, 3 and 5 only in the treatment group. Twenty-three per cent in the treatment group and 30.8% per cent in the placebo group experienced complete resolution of SRF. A significant improvement in BCVA was noted in the placebo group at 4 months, as well as a significant difference in BCVA between groups at 3 months in favour of the placebo group (p = 0.005). There was no significant difference in choroidal thickness in either group throughout the study period. No adverse events related to eplerenone were noted in the treatment group. Conclusion: In this study, eplerenone was not found to be superior to placebo in eyes with chronic CSC.

Original languageEnglish
Pages (from-to)e610-e618
JournalActa Ophthalmologica
Issue number7
StatePublished - Nov 2017


  • CSC
  • central serous chorioretinopathy
  • eplerenone
  • mineralocorticoid receptor antagonist


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