TY - JOUR
T1 - Epitranscriptomics
T2 - regulation of mRNA metabolism through modifications
AU - Peer, Eyal
AU - Rechavi, Gideon
AU - Dominissini, Dan
N1 - Publisher Copyright:
© 2017
PY - 2017/12
Y1 - 2017/12
N2 - Cellular RNAs can be modified post-transcriptionally with dynamic and reversible chemical modifications. These modifications can alter the structure and metabolism of mRNA, but only recent methodological and conceptual advances allowed systematic mapping and functional analysis to unfold the role they play in mRNA biology. Mapping the most common internal mRNA modification, N6-methyladenosine (m6A), paved the way for the deciphering of other types of mRNA modifications, such as N1-methyladenosine (m1A). RNA methylation provides dynamic regulation to the processing, export, translation and stability of mRNA molecules, thereby influencing fundamental biological and pathological processes such as differentiation, cellular response to stress and tumorigenesis. This review summarizes the key methods and the recent discoveries in the field of epitranscriptomics through the prism of post-transcriptional mRNA methylation in eukaryotes.
AB - Cellular RNAs can be modified post-transcriptionally with dynamic and reversible chemical modifications. These modifications can alter the structure and metabolism of mRNA, but only recent methodological and conceptual advances allowed systematic mapping and functional analysis to unfold the role they play in mRNA biology. Mapping the most common internal mRNA modification, N6-methyladenosine (m6A), paved the way for the deciphering of other types of mRNA modifications, such as N1-methyladenosine (m1A). RNA methylation provides dynamic regulation to the processing, export, translation and stability of mRNA molecules, thereby influencing fundamental biological and pathological processes such as differentiation, cellular response to stress and tumorigenesis. This review summarizes the key methods and the recent discoveries in the field of epitranscriptomics through the prism of post-transcriptional mRNA methylation in eukaryotes.
UR - http://www.scopus.com/inward/record.url?scp=85032951040&partnerID=8YFLogxK
U2 - 10.1016/j.cbpa.2017.10.008
DO - 10.1016/j.cbpa.2017.10.008
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 29125941
AN - SCOPUS:85032951040
SN - 1367-5931
VL - 41
SP - 93
EP - 98
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
ER -