Epithelial ovarian cancer, infertility and induction of ovulation: Possible pathogenesis and updated concepts

R. Goshen*, A. Weissman, Z. Shoham

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Numerous case-control, cohort studies, case reports and reviews have been published during the last 5 years regarding the association between infertility and induction of ovulation and epithelial ovarian cancer. Despite this amount of published material, final conclusions regarding direct linkage between these different aspects of infertility and ovarian cancer, as well as any data relating to a putative pathogenetic mechanism, cannot be drawn. In this review we summarize the available data as well as update a previous review by Shoham published in 1994. We outline some of the information that has become available from basic research which may help to direct investigators to suitable clinical research models that may eventually serve to clarify this enigma. Finally we share ideas that focus on specific high-risk cohorts.

Original languageEnglish
Pages (from-to)581-591
Number of pages11
JournalBailliere's Clinical Obstetrics and Gynaecology
Volume12
Issue number4
DOIs
StatePublished - 1998
Externally publishedYes

Funding

FundersFunder number
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institute of Child Health and Human Development
National Cancer Institute
National Institutes of Health

    Keywords

    • Infertility
    • Ovarian carcinoma
    • Ovulation induction

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