Episodic unresponsiveness to single doses of L-dopa in parkinsonian fluctuators

Eldad Melamed*, Victor Bitton, Orly Zelig

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Episodic total unresponsiveness to single doses of L-dopa developed in 14 of 32 parkinsonians with declining efficacy and response fluctuations after chronic L-dopa therapy. Complete lack of clinical benefit after occasional doses was unpredictable, occurred at least once daily mostly in the afternoon, and differed from other response failures related to food intake. In two patients, total unresponsiveness after dose ingestion coincided with lack of increases in plasma L-dopa levels suggesting that phenomenon was due, in part, to failure of L-dopa absorption from the gut.

Original languageEnglish
Pages (from-to)100-103
Number of pages4
JournalNeurology
Volume36
Issue number1
DOIs
StatePublished - Jan 1986
Externally publishedYes

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