Epiretinal Membrane in Patients with Diabetic Macular Edema

Gilad Rabina*, Assaf Hilely, Dana Barequet, Shai Cohen, Naama Lipin, Michael Mimouni, Adina Glick, Adiel Barak, Anat Loewenstein, Shulamit Schwartz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Purpose: The aim of the study was to compare anatomical and functional outcomes of pars plana vitrectomy (PPV) with epiretinal membrane (ERM) peeling in diabetes retinopathy patients with and without diabetic macular edema (DME). Methods: A retrospective interventional case series of consecutive patients who underwent PPV with ERM peeling. Patients were divided into two groups: those with and without preoperative DME. Visual acuity (VA) and optical coherence tomography parameters were evaluated before surgery and during 12 months of follow-up. Results: A total of 354 patients underwent PPV with ERM peeling, of which 51 met the inclusion criteria. Twenty-three were diagnosed with DME and were younger (66.3 ± 9.6 vs. 73.1 ± 8.2 years, p = 0.001), had longer diabetes mellitus (DM) duration (18.9 ± 7.1 vs. 14.3 ± 10.9 years, p = 0.04) and higher HbA1C% (7.6 ± 1.4 vs. 7.1 ± 1.3, p = 0.04). VA improved from 20/105 to 20/60 Snellen (p = 0.004) and central macular thickness decreased from 469.3 ± 64.9 μm to 331.1 ± 92.2 μm (p < 0.001) in the DME group and from 20/87 to 20/44 Snellen (p < 0.001) and from 463.1 ± 53.5 μm to 341.3 ± 49.5 μm (p = 0.01) in the non-DME group. Yearly intravitreal injection rate decreased from 5.9 ± 2.5 to 2.9 ± 3.0 (p < 0.001) injections in the DME group. Conclusions: DME patients with ERM experience significant improvement in VA, macular thickness, and yearly intravitreal injections after PPV with ERM peeling. DME patients are younger, with longer duration of DM and higher HbA1C% levels at presentation in comparison to diabetic ERM patients without DME.

Original languageEnglish
Pages (from-to)446-454
Number of pages9
Issue number5
StatePublished - 1 Nov 2022


  • Diabetes mellitus
  • Diabetic macular edema
  • Epiretinal membrane
  • Optical coherence tomography
  • Pars plana vitrectomy


Dive into the research topics of 'Epiretinal Membrane in Patients with Diabetic Macular Edema'. Together they form a unique fingerprint.

Cite this