Epileptogenic activity in the amygdala is not affected by the amidine steroid, R 5135

O. Kofman, R. Tarrasch, M. Mintz, Myslobodsky M.S.

Research output: Contribution to journalArticlepeer-review

Abstract

The synthetic steroid amidine 3-α-hydroxy-16-imino-5-β-17aza androstan-11-one (R 5135) is known to elicit long-lasting spiking in the cortex in the presence of neocortical damage. R 5135 administered to amygdaloid-kindled and naive rats resulted in regular, high-amplitude spiking in the cortex but only occasionally elicited small-amplitude spikes in the amygdala (AMY) and hippocampus (HPC). Interictal spikes from the AMY of kindled rats were not synchronized with cortical spikes induced by the steroid. Given that R 5135 is known to be a GABAA receptor antagonist, these findings suggest that GABAA receptors in AMY and HPC may have lower affinity for 3α-hydroxysteroids.

Original languageEnglish
Pages (from-to)511-514
Number of pages4
JournalBrain Research Bulletin
Volume29
Issue number3-4
DOIs
StatePublished - 1992

Keywords

  • Amygdala Epilepsy Scizures Steroid Amidine R 5135

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