Abstract
Melanoma brain metastasis is a complication with rising incidence. Despite the high rate of somatic mutations driving the initial stages of melanocyte transformation, the brain colonization requires a phenotypic reprogramming that is, in part, influenced by epigenomic modifications. This special report summarizes recent findings in the epigenomic landscape of melanoma progression to brain metastasis, with particular emphasis on the clinical utility of DNA methylation, chromatin modifications and ncRNA expression as theragnostic markers, as well as the significance of the metastatic microenvironment on melanoma brain metastasis epigenome.
| Original language | English |
|---|---|
| Pages (from-to) | 1303-1311 |
| Number of pages | 9 |
| Journal | Epigenomics |
| Volume | 7 |
| Issue number | 8 |
| DOIs | |
| State | Published - Dec 2015 |
Funding
| Funders | Funder number |
|---|---|
| National Institutes of Health | |
| National Cancer Institute | R01CA167967 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cancer progression
- DNA methylation
- chromatin modifications
- epigenomics
- melanoma brain metastasis
- metastasis microenvironment
- noncoding RNA expression
- regulatory elements
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