Epigenetic loss of m1A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome

Rosaura Esteve-Puig; Fina Climent; David Piñeyro; Eva Domingo-Domènech; Veronica Davalos; Maite Encuentra; Anna Rea; Nadia Espejo-Herrera; Marta Soler; Miguel Lopez; Vanessa Ortiz-Barahona; Gustavo Tapia; José Tomás Navarro; Joan Cid; Lourdes Farré; Alberto Villanueva; Isolda Casanova; Ramon Mangues; Pablo Santamarina-Ojeda; Agustín F. Fernández; Mario F. Fraga; Miguel Angel Piris; Nitzan Kol; Chen Avrahami; Sharon Moshitch-Moshkovitz; Gideon Rechavi; Anna Sureda; Manel Esteller

doi:10.1182/blood.2020005823

Epigenetic loss of m¹A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome

Rosaura Esteve-Puig, Fina Climent, David Piñeyro, Eva Domingo-Domènech, Veronica Davalos, Maite Encuentra, Anna Rea, Nadia Espejo-Herrera, Marta Soler, Miguel Lopez, Vanessa Ortiz-Barahona, Gustavo Tapia, José Tomás Navarro, Joan Cid, Lourdes Farré, Alberto Villanueva, Isolda Casanova, Ramon Mangues, Pablo Santamarina-Ojeda, Agustín F. FernándezMario F. Fraga, Miguel Angel Piris, Nitzan Kol, Chen Avrahami, Sharon Moshitch-Moshkovitz, Gideon Rechavi, Anna Sureda^*, Manel Esteller^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Original language	English
Pages (from-to)	994-999
Number of pages	6
Journal	Blood
Volume	137
Issue number	7
DOIs	https://doi.org/10.1182/blood.2020005823
State	Published - 18 Feb 2021

Funding

Funders	Funder number
Spanish Association Against Cancer
Ministerio de Ciencia e Innovación
Xarxa de Bancs de Tumors de Catalunya
Generalitat de Catalunya
Fundación Científica Asociación Española Contra el Cáncer
de Catalunya
Agencia Estatal de Investigación
Fundación Cellex
Health Department Pla Estratègic de Recerca i Innovació en Salut
European Research Council
Horizon 2020 Framework Programme	743168
PERIS	SLT/002/16/00374
European Regional Development Fund	RTI2018-094049-B-I00
Horizon 2020	Bp17-165
Banking Foundation	LCF/PR/GN18/51140001
Instituto de Salud Carlos III	PT17/0015/0024
Agència de Gestió d'Ajuts Universitaris i de Recerca	2017SGR1080

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1182/blood.2020005823

Cite this

Esteve-Puig, R., Climent, F., Piñeyro, D., Domingo-Domènech, E., Davalos, V., Encuentra, M., Rea, A., Espejo-Herrera, N., Soler, M., Lopez, M., Ortiz-Barahona, V., Tapia, G., Navarro, J. T., Cid, J., Farré, L., Villanueva, A., Casanova, I., Mangues, R., Santamarina-Ojeda, P., ... Esteller, M. (2021). Epigenetic loss of m¹A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome. Blood, 137(7), 994-999. https://doi.org/10.1182/blood.2020005823

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title = "Epigenetic loss of m1A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome",

author = "Rosaura Esteve-Puig and Fina Climent and David Pi{\~n}eyro and Eva Domingo-Dom{\`e}nech and Veronica Davalos and Maite Encuentra and Anna Rea and Nadia Espejo-Herrera and Marta Soler and Miguel Lopez and Vanessa Ortiz-Barahona and Gustavo Tapia and Navarro, {Jos{\'e} Tom{\'a}s} and Joan Cid and Lourdes Farr{\'e} and Alberto Villanueva and Isolda Casanova and Ramon Mangues and Pablo Santamarina-Ojeda and Fern{\'a}ndez, {Agust{\'i}n F.} and Fraga, {Mario F.} and Piris, {Miguel Angel} and Nitzan Kol and Chen Avrahami and Sharon Moshitch-Moshkovitz and Gideon Rechavi and Anna Sureda and Manel Esteller",

note = "Funding Information: The authors thank Centres de Recerca de Catalunya (CERCA) Programme/Generalitat de Catalunya for institutional support. This work was supported by the Health Department Pla Estrat{\`e}gic de Recerca i Innovaci{\'o} en Salut (PERIS) project no. SLT/002/16/00374 and Ag{\`e}ncia de Gesti{\'o} d'Ajuts Universitaris i de Recerca (AGAUR) projects no. 2017SGR1080 of the Catalan Government (Generalitat de Catalunya), Ministerio de Ciencia e Innovaci{\'o}n (MCI), Agencia Estatal de Investigaci{\'o}n (AEI) and European Regional Development Fund (ERDF) project no. RTI2018-094049-B-I00, the Cellex Foundation; “la Caixa” Banking Foundation (LCF/PR/GN18/51140001), the Instituto de Salud Carlos III (PT17/0015/0024), the Xarxa de Bancs de Tumors de Catalunya (XBTC) sponsored by Pla Director d'Oncologia de Catalunya (XBTC) and the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant agreement No. 743168). P.S.-O. is a fellow of the Severo Ochoa Program (Bp17-165). V.D. is supported by the Spanish Association Against Cancer (AECC). Funding Information: This work was supported by the Health Department Pla Estrat{\`e}gic de Recerca i Innovaci{\'o} en Salut (PERIS) project no. SLT/002/16/00374 and Ag{\`e}ncia de Gesti{\'o} d'Ajuts Universitaris i de Recerca (AGAUR) projects no. 2017SGR1080 of the Catalan Government (Generalitat de Catalunya), Ministerio de Ciencia e Innovaci{\'o}n (MCI), Agencia Estatal de Investigaci{\'o}n (AEI) and European Regional Development Fund (ERDF) project no. RTI2018-094049-B-I00, the Cellex Foundation; “la Caixa” Banking Foundation (LCF/PR/GN18/51140001), the Instituto de Salud Carlos III (PT17/0015/0024), the Xarxa de Bancs de Tumors de Catalunya (XBTC) sponsored by Pla Director d'Oncologia de Catalunya (XBTC) and the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant agreement No. 743168). P.S.-O. is a fellow of the Severo Ochoa Program (Bp17-165). V.D. is supported by the Spanish Association Against Cancer (AECC). ",

year = "2021",

month = feb,

day = "18",

doi = "10.1182/blood.2020005823",

language = "אנגלית",

volume = "137",

pages = "994--999",

journal = "Blood",

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Esteve-Puig, R, Climent, F, Piñeyro, D, Domingo-Domènech, E, Davalos, V, Encuentra, M, Rea, A, Espejo-Herrera, N, Soler, M, Lopez, M, Ortiz-Barahona, V, Tapia, G, Navarro, JT, Cid, J, Farré, L, Villanueva, A, Casanova, I, Mangues, R, Santamarina-Ojeda, P, Fernández, AF, Fraga, MF, Piris, MA, Kol, N, Avrahami, C, Moshitch-Moshkovitz, S , Rechavi, G, Sureda, A & Esteller, M 2021, 'Epigenetic loss of m¹A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome', Blood, vol. 137, no. 7, pp. 994-999. https://doi.org/10.1182/blood.2020005823

TY - JOUR

T1 - Epigenetic loss of m1A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome

AU - Esteve-Puig, Rosaura

AU - Climent, Fina

AU - Piñeyro, David

AU - Domingo-Domènech, Eva

AU - Davalos, Veronica

AU - Encuentra, Maite

AU - Rea, Anna

AU - Espejo-Herrera, Nadia

AU - Soler, Marta

AU - Lopez, Miguel

AU - Ortiz-Barahona, Vanessa

AU - Tapia, Gustavo

AU - Navarro, José Tomás

AU - Cid, Joan

AU - Farré, Lourdes

AU - Villanueva, Alberto

AU - Casanova, Isolda

AU - Mangues, Ramon

AU - Santamarina-Ojeda, Pablo

AU - Fernández, Agustín F.

AU - Fraga, Mario F.

AU - Piris, Miguel Angel

AU - Kol, Nitzan

AU - Avrahami, Chen

AU - Moshitch-Moshkovitz, Sharon

AU - Rechavi, Gideon

AU - Sureda, Anna

AU - Esteller, Manel

N1 - Funding Information: The authors thank Centres de Recerca de Catalunya (CERCA) Programme/Generalitat de Catalunya for institutional support. This work was supported by the Health Department Pla Estratègic de Recerca i Innovació en Salut (PERIS) project no. SLT/002/16/00374 and Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) projects no. 2017SGR1080 of the Catalan Government (Generalitat de Catalunya), Ministerio de Ciencia e Innovación (MCI), Agencia Estatal de Investigación (AEI) and European Regional Development Fund (ERDF) project no. RTI2018-094049-B-I00, the Cellex Foundation; “la Caixa” Banking Foundation (LCF/PR/GN18/51140001), the Instituto de Salud Carlos III (PT17/0015/0024), the Xarxa de Bancs de Tumors de Catalunya (XBTC) sponsored by Pla Director d'Oncologia de Catalunya (XBTC) and the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant agreement No. 743168). P.S.-O. is a fellow of the Severo Ochoa Program (Bp17-165). V.D. is supported by the Spanish Association Against Cancer (AECC). Funding Information: This work was supported by the Health Department Pla Estratègic de Recerca i Innovació en Salut (PERIS) project no. SLT/002/16/00374 and Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) projects no. 2017SGR1080 of the Catalan Government (Generalitat de Catalunya), Ministerio de Ciencia e Innovación (MCI), Agencia Estatal de Investigación (AEI) and European Regional Development Fund (ERDF) project no. RTI2018-094049-B-I00, the Cellex Foundation; “la Caixa” Banking Foundation (LCF/PR/GN18/51140001), the Instituto de Salud Carlos III (PT17/0015/0024), the Xarxa de Bancs de Tumors de Catalunya (XBTC) sponsored by Pla Director d'Oncologia de Catalunya (XBTC) and the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (Grant agreement No. 743168). P.S.-O. is a fellow of the Severo Ochoa Program (Bp17-165). V.D. is supported by the Spanish Association Against Cancer (AECC).

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