TY - JOUR
T1 - Epidemiology of pediatric meningitis caused by haemophilus influenzae type b, streptococcus pneumoniae, and neisseria meningitidis in israel
T2 - A 3-year nationwide prospective study
AU - Jacob Amir for the Israeli Pediatric Bacteremia and Meningitis Group
AU - Dagan, Ron
AU - Isaachson, Meir
AU - Lang, Ruth
AU - Karpuch, Julio
AU - Block, Colin
AU - Amir, Jacob
AU - Block, Colin
AU - Dan, Michael
AU - Drucker, Moshe
AU - Ephros, Moshe
AU - Engelhard, Dan
AU - Faivisevitz, Adir
AU - Finkelstein, Renalto
AU - Greif, Zvi
AU - Kovarsky, Masha
AU - Isacchson, Meir
AU - Kaufstein, Miriam
AU - Karpuch, Julio
AU - Lang, Ruth
AU - Linden, Amos
AU - Raz, Raul
AU - Potasman, Israel
AU - Segal, Dora K.
AU - Shalit, Hamar
AU - Shazberg, Gila
AU - Shoukri, Atalla
AU - Schlezinger, Menachem
AU - Schreiber, Mordechai
PY - 1994/4/1
Y1 - 1994/4/1
N2 - In a 3-year nationwide prospective study on pediatric meningitis caused by Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis in Israel, 1258 invasive infections with a known focus were observed. Meningitis was found in 482 (38%): 56%, 16%, and 76% of all infections by H. influenzae type b, S. pneumoniae, and N. meningitidis, respectively. The incidence of meningitis during the first year of life was 67.1, 17.5, and 9.5/100, 000 for H. influenzae type b, S. pneumoniae, and N. meningitidis, respectively, and in children <5 years old it was 18.5, 5.3, and 5.2. Extrapolated for a population in which 100, 000 live births occur yearly, 2097 hospital days were required. The case fatality rate was 2.2%, 5.9%, and 6.3% for H. influenzae type b, S. pneumoniae, and N. meningitidis, respectively. Boys were affected significantly more often than girls, but mortality was higher among girls. On the basis of the observed serotypes and age distribution, even with optimal vaccine development in the next 5 years, it is not likely that >50% of all cases will be prevented.
AB - In a 3-year nationwide prospective study on pediatric meningitis caused by Haemophilus influenzae type b, Streptococcus pneumoniae, and Neisseria meningitidis in Israel, 1258 invasive infections with a known focus were observed. Meningitis was found in 482 (38%): 56%, 16%, and 76% of all infections by H. influenzae type b, S. pneumoniae, and N. meningitidis, respectively. The incidence of meningitis during the first year of life was 67.1, 17.5, and 9.5/100, 000 for H. influenzae type b, S. pneumoniae, and N. meningitidis, respectively, and in children <5 years old it was 18.5, 5.3, and 5.2. Extrapolated for a population in which 100, 000 live births occur yearly, 2097 hospital days were required. The case fatality rate was 2.2%, 5.9%, and 6.3% for H. influenzae type b, S. pneumoniae, and N. meningitidis, respectively. Boys were affected significantly more often than girls, but mortality was higher among girls. On the basis of the observed serotypes and age distribution, even with optimal vaccine development in the next 5 years, it is not likely that >50% of all cases will be prevented.
UR - http://www.scopus.com/inward/record.url?scp=0028346961&partnerID=8YFLogxK
U2 - 10.1093/infdis/169.4.912
DO - 10.1093/infdis/169.4.912
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AN - SCOPUS:0028346961
SN - 0022-1899
VL - 169
SP - 912
EP - 916
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -