TY - JOUR
T1 - Epidemiology of gliomas in Israel
T2 - A nationwide study
AU - Sadetzki, Siegal
AU - Zach, Leor
AU - Chetrit, Angela
AU - Nass, Dvora
AU - Hoffmann, Chen
AU - Ram, Zvi
AU - Zaaroor, Menashe
AU - Umansky, Felix
AU - Rappaport, Zvi Harry
AU - Cohen, Avi
AU - Wald, Uriel
AU - Rothman, Sigmund
AU - Hadani, Moshe
PY - 2008/11
Y1 - 2008/11
N2 - Background: Glial brain tumors span a wide range of neoplasms with distinct clinical and histopathological features. This report presents the descriptive epidemiology of glial tumors by histological subtype and tumor behavior. Methods: The study population included all incident cases of glial tumors diagnosed in Israel during March 2001 to July 2003. Age-standardized incidence rates (ASR) were calculated using the world population as a standard. Results: A total of 548 tumors were diagnosed, of which 520 had histological confirmation. The ASR of all adult (>20 years) glial tumors was 5.82/100,000 (7.11 for males; 4.75 for females, p < 0.001). The majority of tumors (78%) were classified as high grade; astrocytic tumors were the most frequent (85%), with glioblastoma multiforme accounting for 70% of them. A significant positive association was shown between age at diagnosis and grade. The highest ASR was seen for Europe- and-American-born, followed by Israeli, Asian and African-born individuals (6.78, 5.86, 4.94 and 3.84/100,000, respectively). Conclusions: In general, these results describing data of incident cases of pathologically validated glial tumors are consistent with previous reports. To enhance our understanding of these diseases, epidemiological studies should rely on well-defined histological tumor types, incorporating comprehensive information which will allow comparability between different groups of patients.
AB - Background: Glial brain tumors span a wide range of neoplasms with distinct clinical and histopathological features. This report presents the descriptive epidemiology of glial tumors by histological subtype and tumor behavior. Methods: The study population included all incident cases of glial tumors diagnosed in Israel during March 2001 to July 2003. Age-standardized incidence rates (ASR) were calculated using the world population as a standard. Results: A total of 548 tumors were diagnosed, of which 520 had histological confirmation. The ASR of all adult (>20 years) glial tumors was 5.82/100,000 (7.11 for males; 4.75 for females, p < 0.001). The majority of tumors (78%) were classified as high grade; astrocytic tumors were the most frequent (85%), with glioblastoma multiforme accounting for 70% of them. A significant positive association was shown between age at diagnosis and grade. The highest ASR was seen for Europe- and-American-born, followed by Israeli, Asian and African-born individuals (6.78, 5.86, 4.94 and 3.84/100,000, respectively). Conclusions: In general, these results describing data of incident cases of pathologically validated glial tumors are consistent with previous reports. To enhance our understanding of these diseases, epidemiological studies should rely on well-defined histological tumor types, incorporating comprehensive information which will allow comparability between different groups of patients.
KW - Descriptive epidemiology, Israel
KW - Glioma, incidence rates
UR - http://www.scopus.com/inward/record.url?scp=53849110305&partnerID=8YFLogxK
U2 - 10.1159/000165366
DO - 10.1159/000165366
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AN - SCOPUS:53849110305
SN - 0251-5350
VL - 31
SP - 264
EP - 269
JO - Neuroepidemiology
JF - Neuroepidemiology
IS - 4
ER -