Epidemiology of cryptosporidiosis among European AIDS patients

C. Pedersen; S. Danner; A. Lazzarin; M. P. Glauser; R. Weber; C. Katlama; S. E. Barton; J. D. Lundgren; N. Clumeck; S. Dewit; B. Sommereijns; J. O. Nielsen; T. Nielsen; G. Jensen; P. Skinhøj; K. Bentsen; J. Gerstoft; M. Melbye; A. Ranki; S. L. Valle; P. Berlureau; M. Dietrich; S. Schwander; F. D. Goebel; J. Kosmidis; G. Stergiou; T. Gouzia; A. Papadopoulos; D. Banhegyi; F. Mulcahy; I. Yust; Z. Ben-Ishai; Z. Bentwich; T. Sacks; S. Maayan; S. Velia; A. Chiesi; F. Ancarani; G. Scalise; A. Bertaggia; E. Francavilla; G. Calonghi; A. Cargnel; M. Arlotti; R. Ciammarughi; A. Colomba; F. Delalla; P. Fassio; A. Ferlini; F. Fiaccadori; G. Pasetti; F. Giannelli; W. Grillone; A. D'arminio Monforte; E. Mignani; A. Nunnari; L. Ortona; G. Panichi; S. Pauluzzi; N. Piersantelli; S. Ranieri; P. Ricciardiello; B. Roscioli; M. Soranzo; R. Hemmer; Peter Reiss; F. Antunes; R. Proenca; J. Gonzilez-Lahoz; Rosa Polo; B. Clotet; J. Gatell; E. Buira; J. Miro; P. Pehrson; R. Liithy; B. Ledergerber; C. Olsson; M. Glauser; B. Hirschel; A. Johnson; S. Hawkes; A. Phillips; S. Barton; J. Morcinek; A. Pinching; D. Coleman; I. Gjørup; J. Nielsen; C. Nieport; L. Teglbjaerg; A. Thomval

doi:10.1136/sti.72.2.128

Epidemiology of cryptosporidiosis among European AIDS patients

C. Pedersen^*, S. Danner, A. Lazzarin, M. P. Glauser, R. Weber, C. Katlama, S. E. Barton, J. D. Lundgren, N. Clumeck, S. Dewit, B. Sommereijns, J. O. Nielsen, T. Nielsen, G. Jensen, P. Skinhøj, K. Bentsen, J. Gerstoft, M. Melbye, A. Ranki, S. L. ValleP. Berlureau, M. Dietrich, S. Schwander, F. D. Goebel, J. Kosmidis, G. Stergiou, T. Gouzia, A. Papadopoulos, D. Banhegyi, F. Mulcahy, I. Yust, Z. Ben-Ishai, Z. Bentwich, T. Sacks, S. Maayan, S. Velia, A. Chiesi, F. Ancarani, G. Scalise, A. Bertaggia, E. Francavilla, G. Calonghi, A. Cargnel, M. Arlotti, R. Ciammarughi, A. Colomba, F. Delalla, P. Fassio, A. Ferlini, F. Fiaccadori, G. Pasetti, F. Giannelli, W. Grillone, A. D'arminio Monforte, E. Mignani, A. Nunnari, L. Ortona, G. Panichi, S. Pauluzzi, N. Piersantelli, S. Ranieri, P. Ricciardiello, B. Roscioli, M. Soranzo, R. Hemmer, Peter Reiss, F. Antunes, R. Proenca, J. Gonzilez-Lahoz, Rosa Polo, B. Clotet, J. Gatell, E. Buira, J. Miro, P. Pehrson, R. Liithy, B. Ledergerber, C. Olsson, M. Glauser, B. Hirschel, A. Johnson, S. Hawkes, A. Phillips, S. Barton, J. Morcinek, A. Pinching, D. Coleman, I. Gjørup, J. Nielsen, C. Nieport, L. Teglbjaerg, A. Thomval

^*Corresponding author for this work

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Abstract

Objective: To study epidemiology and possible risk factors associated with the development of cryptosporidiosis among European patients with AIDS. Methods: An inception cohort of 6548 patients with AIDS, consecutively diagnosed from 1979 to 1989, from 52 centres in 17 European countries was studied. Data on all AIDS defining events were collected retrospectively from patients' clinical records. Kaplan-Meier estimates, log rank tests and Cox proportional hazard models were used to examine for possible risk factors associated with cryptosporidiosis. Results: Cryptosporidiosis was diagnosed in 432 (6.6%) patients, 216 at time of the AIDS diagnosis and 216 during follow-up. The probability of being diagnosed with cryptosporidiosis at AIDS diagnosis was significantly lower for intravenous drug users (1.3%) than for homosexual men (4.1%) and for patients belonging to other transmission categories (4.0%) (p < 0.001). The probability was also higher for patients from Central Europe compared with patients from South Europe (4.1% versus 2.5%, p = 0.005). The rate of developing cryptosporidiosis after the diagnosis of AIDS was 3 per 100 patient years of follow-up. The rate was significantly lower for intravenous' drug users than for homosexual men (relative risk 0.34, 95% confidence limits 0.22-0.54) and for women compared with men (RR 0.43 (0.21-0.87)). The risk was higher in North Europe than in South and Central Europe. In a multivariate analysis only transmission category remained a significant predictor for the development of cryptosporidiosis. Conclusion: The development of cryptosporidiosis in AIDS patients may be associated with sexual risk behaviour.

Original language	English
Pages (from-to)	128-131
Number of pages	4
Journal	Genitourinary Medicine
Volume	72
Issue number	2
DOIs	https://doi.org/10.1136/sti.72.2.128
State	Published - 1996
Externally published	Yes

Keywords

AIDS
Cryptosporidia
Cryptosporidiosis
Epidemiology
HIV

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/sti.72.2.128

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Pedersen, C., Danner, S., Lazzarin, A., Glauser, M. P., Weber, R., Katlama, C., Barton, S. E., Lundgren, J. D., Clumeck, N., Dewit, S., Sommereijns, B., Nielsen, J. O., Nielsen, T., Jensen, G., Skinhøj, P., Bentsen, K., Gerstoft, J., Melbye, M., Ranki, A., ... Thomval, A. (1996). Epidemiology of cryptosporidiosis among European AIDS patients. Genitourinary Medicine, 72(2), 128-131. https://doi.org/10.1136/sti.72.2.128

@article{854d005dec894dbaa00751970af44d66,

title = "Epidemiology of cryptosporidiosis among European AIDS patients",

abstract = "Objective: To study epidemiology and possible risk factors associated with the development of cryptosporidiosis among European patients with AIDS. Methods: An inception cohort of 6548 patients with AIDS, consecutively diagnosed from 1979 to 1989, from 52 centres in 17 European countries was studied. Data on all AIDS defining events were collected retrospectively from patients' clinical records. Kaplan-Meier estimates, log rank tests and Cox proportional hazard models were used to examine for possible risk factors associated with cryptosporidiosis. Results: Cryptosporidiosis was diagnosed in 432 (6.6%) patients, 216 at time of the AIDS diagnosis and 216 during follow-up. The probability of being diagnosed with cryptosporidiosis at AIDS diagnosis was significantly lower for intravenous drug users (1.3%) than for homosexual men (4.1%) and for patients belonging to other transmission categories (4.0%) (p < 0.001). The probability was also higher for patients from Central Europe compared with patients from South Europe (4.1% versus 2.5%, p = 0.005). The rate of developing cryptosporidiosis after the diagnosis of AIDS was 3 per 100 patient years of follow-up. The rate was significantly lower for intravenous' drug users than for homosexual men (relative risk 0.34, 95% confidence limits 0.22-0.54) and for women compared with men (RR 0.43 (0.21-0.87)). The risk was higher in North Europe than in South and Central Europe. In a multivariate analysis only transmission category remained a significant predictor for the development of cryptosporidiosis. Conclusion: The development of cryptosporidiosis in AIDS patients may be associated with sexual risk behaviour.",

keywords = "AIDS, Cryptosporidia, Cryptosporidiosis, Epidemiology, HIV",

author = "C. Pedersen and S. Danner and A. Lazzarin and Glauser, {M. P.} and R. Weber and C. Katlama and Barton, {S. E.} and Lundgren, {J. D.} and N. Clumeck and S. Dewit and B. Sommereijns and Nielsen, {J. O.} and T. Nielsen and G. Jensen and P. Skinh{\o}j and K. Bentsen and J. Gerstoft and M. Melbye and A. Ranki and Valle, {S. L.} and P. Berlureau and M. Dietrich and S. Schwander and Goebel, {F. D.} and J. Kosmidis and G. Stergiou and T. Gouzia and A. Papadopoulos and D. Banhegyi and F. Mulcahy and I. Yust and Z. Ben-Ishai and Z. Bentwich and T. Sacks and S. Maayan and S. Velia and A. Chiesi and F. Ancarani and G. Scalise and A. Bertaggia and E. Francavilla and G. Calonghi and A. Cargnel and M. Arlotti and R. Ciammarughi and A. Colomba and F. Delalla and P. Fassio and A. Ferlini and F. Fiaccadori and G. Pasetti and F. Giannelli and W. Grillone and {D'arminio Monforte}, A. and E. Mignani and A. Nunnari and L. Ortona and G. Panichi and S. Pauluzzi and N. Piersantelli and S. Ranieri and P. Ricciardiello and B. Roscioli and M. Soranzo and R. Hemmer and Peter Reiss and F. Antunes and R. Proenca and J. Gonzilez-Lahoz and Rosa Polo and B. Clotet and J. Gatell and E. Buira and J. Miro and P. Pehrson and R. Liithy and B. Ledergerber and C. Olsson and M. Glauser and B. Hirschel and A. Johnson and S. Hawkes and A. Phillips and S. Barton and J. Morcinek and A. Pinching and D. Coleman and I. Gj{\o}rup and J. Nielsen and C. Nieport and L. Teglbjaerg and A. Thomval",

year = "1996",

doi = "10.1136/sti.72.2.128",

language = "אנגלית",

volume = "72",

pages = "128--131",

journal = "Genitourinary Medicine",

issn = "0266-4348",

publisher = "BMJ Publishing Group",

number = "2",

}

Pedersen, C, Danner, S, Lazzarin, A, Glauser, MP, Weber, R, Katlama, C, Barton, SE, Lundgren, JD, Clumeck, N, Dewit, S, Sommereijns, B, Nielsen, JO, Nielsen, T, Jensen, G, Skinhøj, P, Bentsen, K, Gerstoft, J, Melbye, M, Ranki, A, Valle, SL, Berlureau, P, Dietrich, M, Schwander, S, Goebel, FD, Kosmidis, J, Stergiou, G, Gouzia, T, Papadopoulos, A, Banhegyi, D, Mulcahy, F, Yust, I, Ben-Ishai, Z, Bentwich, Z, Sacks, T, Maayan, S, Velia, S, Chiesi, A, Ancarani, F, Scalise, G, Bertaggia, A, Francavilla, E, Calonghi, G, Cargnel, A, Arlotti, M, Ciammarughi, R, Colomba, A, Delalla, F, Fassio, P, Ferlini, A, Fiaccadori, F, Pasetti, G, Giannelli, F, Grillone, W, D'arminio Monforte, A, Mignani, E, Nunnari, A, Ortona, L, Panichi, G, Pauluzzi, S, Piersantelli, N, Ranieri, S, Ricciardiello, P, Roscioli, B, Soranzo, M, Hemmer, R, Reiss, P, Antunes, F, Proenca, R, Gonzilez-Lahoz, J, Polo, R, Clotet, B, Gatell, J, Buira, E, Miro, J, Pehrson, P, Liithy, R, Ledergerber, B, Olsson, C, Glauser, M, Hirschel, B, Johnson, A, Hawkes, S, Phillips, A, Barton, S, Morcinek, J, Pinching, A, Coleman, D, Gjørup, I, Nielsen, J, Nieport, C, Teglbjaerg, L & Thomval, A 1996, 'Epidemiology of cryptosporidiosis among European AIDS patients', Genitourinary Medicine, vol. 72, no. 2, pp. 128-131. https://doi.org/10.1136/sti.72.2.128

TY - JOUR

T1 - Epidemiology of cryptosporidiosis among European AIDS patients

AU - Pedersen, C.

AU - Danner, S.

AU - Lazzarin, A.

AU - Glauser, M. P.

AU - Weber, R.

AU - Katlama, C.

AU - Barton, S. E.

AU - Lundgren, J. D.

AU - Clumeck, N.

AU - Dewit, S.

AU - Sommereijns, B.

AU - Nielsen, J. O.

AU - Nielsen, T.

AU - Jensen, G.

AU - Skinhøj, P.

AU - Bentsen, K.

AU - Gerstoft, J.

AU - Melbye, M.

AU - Ranki, A.

AU - Valle, S. L.

AU - Berlureau, P.

AU - Dietrich, M.

AU - Schwander, S.

AU - Goebel, F. D.

AU - Kosmidis, J.

AU - Stergiou, G.

AU - Gouzia, T.

AU - Papadopoulos, A.

AU - Banhegyi, D.

AU - Mulcahy, F.

AU - Yust, I.

AU - Ben-Ishai, Z.

AU - Bentwich, Z.

AU - Sacks, T.

AU - Maayan, S.

AU - Velia, S.

AU - Chiesi, A.

AU - Ancarani, F.

AU - Scalise, G.

AU - Bertaggia, A.

AU - Francavilla, E.

AU - Calonghi, G.

AU - Cargnel, A.

AU - Arlotti, M.

AU - Ciammarughi, R.

AU - Colomba, A.

AU - Delalla, F.

AU - Fassio, P.

AU - Ferlini, A.

AU - Fiaccadori, F.

AU - Pasetti, G.

AU - Giannelli, F.

AU - Grillone, W.

AU - D'arminio Monforte, A.

AU - Mignani, E.

AU - Nunnari, A.

AU - Ortona, L.

AU - Panichi, G.

AU - Pauluzzi, S.

AU - Piersantelli, N.

AU - Ranieri, S.

AU - Ricciardiello, P.

AU - Roscioli, B.

AU - Soranzo, M.

AU - Hemmer, R.

AU - Reiss, Peter

AU - Antunes, F.

AU - Proenca, R.

AU - Gonzilez-Lahoz, J.

AU - Polo, Rosa

AU - Clotet, B.

AU - Gatell, J.

AU - Buira, E.

AU - Miro, J.

AU - Pehrson, P.

AU - Liithy, R.

AU - Ledergerber, B.

AU - Olsson, C.

AU - Glauser, M.

AU - Hirschel, B.

AU - Johnson, A.

AU - Hawkes, S.

AU - Phillips, A.

AU - Barton, S.

AU - Morcinek, J.

AU - Pinching, A.

AU - Coleman, D.

AU - Gjørup, I.

AU - Nielsen, J.

AU - Nieport, C.

AU - Teglbjaerg, L.

AU - Thomval, A.

PY - 1996

Y1 - 1996

N2 - Objective: To study epidemiology and possible risk factors associated with the development of cryptosporidiosis among European patients with AIDS. Methods: An inception cohort of 6548 patients with AIDS, consecutively diagnosed from 1979 to 1989, from 52 centres in 17 European countries was studied. Data on all AIDS defining events were collected retrospectively from patients' clinical records. Kaplan-Meier estimates, log rank tests and Cox proportional hazard models were used to examine for possible risk factors associated with cryptosporidiosis. Results: Cryptosporidiosis was diagnosed in 432 (6.6%) patients, 216 at time of the AIDS diagnosis and 216 during follow-up. The probability of being diagnosed with cryptosporidiosis at AIDS diagnosis was significantly lower for intravenous drug users (1.3%) than for homosexual men (4.1%) and for patients belonging to other transmission categories (4.0%) (p < 0.001). The probability was also higher for patients from Central Europe compared with patients from South Europe (4.1% versus 2.5%, p = 0.005). The rate of developing cryptosporidiosis after the diagnosis of AIDS was 3 per 100 patient years of follow-up. The rate was significantly lower for intravenous' drug users than for homosexual men (relative risk 0.34, 95% confidence limits 0.22-0.54) and for women compared with men (RR 0.43 (0.21-0.87)). The risk was higher in North Europe than in South and Central Europe. In a multivariate analysis only transmission category remained a significant predictor for the development of cryptosporidiosis. Conclusion: The development of cryptosporidiosis in AIDS patients may be associated with sexual risk behaviour.

AB - Objective: To study epidemiology and possible risk factors associated with the development of cryptosporidiosis among European patients with AIDS. Methods: An inception cohort of 6548 patients with AIDS, consecutively diagnosed from 1979 to 1989, from 52 centres in 17 European countries was studied. Data on all AIDS defining events were collected retrospectively from patients' clinical records. Kaplan-Meier estimates, log rank tests and Cox proportional hazard models were used to examine for possible risk factors associated with cryptosporidiosis. Results: Cryptosporidiosis was diagnosed in 432 (6.6%) patients, 216 at time of the AIDS diagnosis and 216 during follow-up. The probability of being diagnosed with cryptosporidiosis at AIDS diagnosis was significantly lower for intravenous drug users (1.3%) than for homosexual men (4.1%) and for patients belonging to other transmission categories (4.0%) (p < 0.001). The probability was also higher for patients from Central Europe compared with patients from South Europe (4.1% versus 2.5%, p = 0.005). The rate of developing cryptosporidiosis after the diagnosis of AIDS was 3 per 100 patient years of follow-up. The rate was significantly lower for intravenous' drug users than for homosexual men (relative risk 0.34, 95% confidence limits 0.22-0.54) and for women compared with men (RR 0.43 (0.21-0.87)). The risk was higher in North Europe than in South and Central Europe. In a multivariate analysis only transmission category remained a significant predictor for the development of cryptosporidiosis. Conclusion: The development of cryptosporidiosis in AIDS patients may be associated with sexual risk behaviour.

KW - AIDS

KW - Cryptosporidia

KW - Cryptosporidiosis

KW - Epidemiology

KW - HIV

UR - http://www.scopus.com/inward/record.url?scp=0029874187&partnerID=8YFLogxK

U2 - 10.1136/sti.72.2.128

DO - 10.1136/sti.72.2.128

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0029874187

SN - 0266-4348

VL - 72

SP - 128

EP - 131

JO - Genitourinary Medicine

JF - Genitourinary Medicine

IS - 2

ER -

Epidemiology of cryptosporidiosis among European AIDS patients

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Keywords

UN SDGs

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