TY - JOUR
T1 - Epidemiological interpretation of studies examining the effect of antibiotic usage on resistance
AU - Schechner, Vered
AU - Temkin, Elizabeth
AU - Harbarth, Stephan
AU - Carmeli, Yehuda
AU - Schwaber, Mitchell J.
PY - 2013/4
Y1 - 2013/4
N2 - Bacterial resistance to antibiotics is a growing clinical problem and public health threat. Antibiotic use is a known risk factor for the emergence of antibiotic resistance, but demonstrating the causal link between antibiotic use and resistance is challenging. This review describes different study designs for assessing the association between antibiotic use and resistance and discusses strengths and limitations of each. Approaches to measuring antibiotic use and antibiotic resistance are presented. Important methodological issues such as confounding, establishing temporality, and control group selection are examined.
AB - Bacterial resistance to antibiotics is a growing clinical problem and public health threat. Antibiotic use is a known risk factor for the emergence of antibiotic resistance, but demonstrating the causal link between antibiotic use and resistance is challenging. This review describes different study designs for assessing the association between antibiotic use and resistance and discusses strengths and limitations of each. Approaches to measuring antibiotic use and antibiotic resistance are presented. Important methodological issues such as confounding, establishing temporality, and control group selection are examined.
UR - http://www.scopus.com/inward/record.url?scp=84875752546&partnerID=8YFLogxK
U2 - 10.1128/CMR.00001-13
DO - 10.1128/CMR.00001-13
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 23554418
AN - SCOPUS:84875752546
SN - 0893-8512
VL - 26
SP - 289
EP - 307
JO - Clinical Microbiology Reviews
JF - Clinical Microbiology Reviews
IS - 2
ER -