Epidemiological and virological characterization of influenza B virus infections

Sivan Sharabi, Yaron Drori, Michal Micheli, Nehemya Friedman, Sara Orzitzer, Ravit Bassal, Aharona Glatman-Freedman, Tamar Shohat, Ella Mendelson, Musa Hindiyeh, Michal Mandelboim

Research output: Contribution to journalArticlepeer-review


While influenza A viruses comprise a heterogeneous group of clinically relevant influenza viruses, influenza B viruses form a more homogeneous cluster, divided mainly into two lineages: Victoria and Yamagata. This divergence has complicated seasonal influenza vaccine design, which traditionally contained two seasonal influenza A virus strains and one influenza B virus strain. We examined the distribution of the two influenza B virus lineages in Israel, between 2011-2014, in hospitalized and in non-hospitalized (community) influenza B virus-infected patients. We showed that influenza B virus infections can lead to hospitalization and demonstrated that during some winter seasons, both influenza B virus lineages circulated simultaneously in Israel. We further show that the influenza B virus Yamagata lineage was dominant, circulating in the county in the last few years of the study period, consistent with the anti-Yamagata influenza B virus antibodies detected in the serum samples of affected individuals residing in Israel in the year 2014. Interestingly, we found that elderly people were particularly vulnerable to Yamagata lineage influenza B virus infections.

Original languageEnglish
Article numbere0161195
JournalPLoS ONE
Issue number8
StatePublished - Aug 2016


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