Epidemiologic evidence for serotype-specific acquired immunity to pneumococcal carriage

Daniel M. Weinberger, Ron Dagan, Noga Givon-Lavi, Gili Regev-Yochay, Richard Malley, Marc Lipsitch

Research output: Contribution to journalArticlepeer-review


Nasopharyngeal carriage of Streptococcus pneumoniae is required for transmission of the bacteria and for invasive disease. There have been conflicting reports as to whether protection against carriage is serotype specific and which immune mechanisms drive carriage. Analyzing longitudinal carriage data from Israeli toddlers in day care, we found a lower risk of colonization with types 6A, 14, and 23F after previous exposure to the homologous type. Nonsignificant trends suggesting possible protection derived from prior exposure were found for types 19A and 23A. Furthermore, we found that, for types 14 and 23F, this specific protection correlated with increased serotype-specific antibody concentration. We found no evidence of specific protection for type 6B, group 15, or type 19F. Our findings imply that at least some serotypes generate anti-capsular antibodies that can reduce the risk of carriage in unimmunized toddlers.

Original languageEnglish
Pages (from-to)1511-1518
Number of pages8
JournalJournal of Infectious Diseases
Issue number11
StatePublished - 1 Jun 2008
Externally publishedYes


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