TY - JOUR
T1 - Ependymomas arising outside of the central nervous system
T2 - A case series and literature review
AU - Yust Katz, Shlomit
AU - Cachia, David
AU - Kamiya Matsuok, Carlos
AU - Olar, Adriana
AU - Theeler, Brett
AU - Penas Prado, Marta
AU - Gilbert, Mark R.
AU - Armstrong, Terri
N1 - Publisher Copyright:
© 2017
PY - 2018/1
Y1 - 2018/1
N2 - Background Extracranial and extraspinal ependymomas are extremely rare tumors mostly published in the literature as case reports. Methods MD Anderson Cancer Center institutional database was screened for patients with extra CNS ependymomas over a 25 year period. Results Eight patients with extra CNS ependymoma were identified. Five cases originated in the sacrum or subcutaneous sacral area, and the other 3 cases originating in the breast, lung and adnexa of the uterus. By histology, most cases were myxopapillary ependymomas (5 cases), 2 cases were grade II ependymoma and 1 case was an anaplastic ependymoma. Metastases occurred in 6 cases and 3 patients died due to progressive disease. Most cases required surgery, radiation and chemotherapy. Conclusion Extra CNS ependymomas are very rare tumors that tend to metastasize, even though most cases are histologically classified as low grade ependymomas.
AB - Background Extracranial and extraspinal ependymomas are extremely rare tumors mostly published in the literature as case reports. Methods MD Anderson Cancer Center institutional database was screened for patients with extra CNS ependymomas over a 25 year period. Results Eight patients with extra CNS ependymoma were identified. Five cases originated in the sacrum or subcutaneous sacral area, and the other 3 cases originating in the breast, lung and adnexa of the uterus. By histology, most cases were myxopapillary ependymomas (5 cases), 2 cases were grade II ependymoma and 1 case was an anaplastic ependymoma. Metastases occurred in 6 cases and 3 patients died due to progressive disease. Most cases required surgery, radiation and chemotherapy. Conclusion Extra CNS ependymomas are very rare tumors that tend to metastasize, even though most cases are histologically classified as low grade ependymomas.
KW - Ependymoma
KW - Extra-CNS
KW - Metastases
UR - http://www.scopus.com/inward/record.url?scp=85031707459&partnerID=8YFLogxK
U2 - 10.1016/j.jocn.2017.10.026
DO - 10.1016/j.jocn.2017.10.026
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C2 - 29054328
AN - SCOPUS:85031707459
SN - 0967-5868
VL - 47
SP - 202
EP - 207
JO - Journal of Clinical Neuroscience
JF - Journal of Clinical Neuroscience
ER -