Eosinophilic granuloma of the spine

Yizhar Floman*, Elhanan Bar-On, Rami Mosheiff, Yigal Mirovsky, Gordon C. Robin, Nili Ramu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Twenty patients treated for eosinophilic granuloma of the spine were studied. Only 40% demonstrated the classical radiographic picture of vertebra plana. In 60% a lyric lesion of the vertebral body or the posterior elements was found. Seven patients underwent surgery; the indications were neurological involvement or failure of the biopsy to disclose the diagnosis. At an average follow-up period of 7 years, 17 patients are well and alive with no residual spinal pain, neurological compromise, recurrent disease, or extraskeletal involvement. Vertebral body collapse underwent some regeneration but did not regain full body height. In several patients this resulted in a local deformity. In patients with unifocal spinal eosinophilic granuloma, watchful observation with no treatment other than spinal support is warranted. In patients with neural involvement or multifocal lesions, a more active treatment, including surgery, may be indicated.

Original languageEnglish
Pages (from-to)260-265
Number of pages6
JournalJournal of Pediatric Orthopaedics Part B
Issue number4
StatePublished - 1997
Externally publishedYes


  • Eosinophilic granuloma
  • Langerhans' cell hystiocytosis
  • Osteolytic lesion
  • Vertebra plana


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