Enzyme replacement therapy in the management of longstanding skeletal and soft tissue salmonella infection in a patient with Gaucher's disease

M. Margalit, N. Ash, Ari Zimran*, H. Halkin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A splenectomised patient with Gaucher's disease who developed multiple foci of osteomyelitis and soft tissue abcesses, after a severe episode of group C salmonella sepsis, is described. Aggressive antibiotic treatment and surgical drainage had little effect and the patient's condition continued to deteriorate. With initiation of enzyme replacement therapy (ERT) in addition to specific antibiotic treatment, defervescence and gradual healing occurred. Complete resolution of the infection was seen after 15 months. The possible role of ERT in healing bacterial infections in Gaucher's disease is discussed.

Original languageEnglish
Pages (from-to)564-565
Number of pages2
JournalPostgraduate Medical Journal
Volume78
Issue number923
DOIs
StatePublished - 1 Sep 2002
Externally publishedYes

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