Enzymatically triggered self-assembly of block copolymers

  • Roey J. Amir
  • , Sheng Zhong
  • , Darrin J. Pochan
  • , Craig J. Hawker

Research output: Contribution to journalArticlepeer-review

147 Scopus citations

Abstract

(Figure Presented) The polymerization of vinyl monomers with cleavable enzymatic substrates has been shown to lead to water-soluble double-hydrophilic block copolymers which, upon enzymatic activation of the diblock copolymers, become amphiphilic and undergo self-assembly into colloidal nanostructures. The ability to change the chemical and physical characteristics of polymeric materials by an enzymatic reaction opens the way for novel and exciting applications such as enzymatic-triggered activation of surfaces and formation of nanostructures in vivo in a highly controlled manner.

Original languageEnglish
Pages (from-to)13949-13951
Number of pages3
JournalJournal of the American Chemical Society
Volume131
Issue number39
DOIs
StatePublished - 7 Oct 2009
Externally publishedYes

Funding

FundersFunder number
National Heart, Lung, and Blood InstituteU01HL080729

    Fingerprint

    Dive into the research topics of 'Enzymatically triggered self-assembly of block copolymers'. Together they form a unique fingerprint.

    Cite this