Environmental surveillance detected type 3 vaccine-derived polioviruses in increasing frequency at multiple sites prior to detection of a poliomyelitis case

Merav Weil; Danit Sofer; Lester M. Shulman; Leah Weiss; Nofar Levi; Irina Aguvaev; Zvi Cohen; Klil Kestin; Rinat Vasserman; Michal Elul; Ilana S. Fratty; Neta S. Zuckerman; Oran Erster; Ruth Yishai; Lior Hecht; Sharon Alroy-Preis; Ella Mendelson; Itay Bar-Or

doi:10.1016/j.scitotenv.2023.161985

Environmental surveillance detected type 3 vaccine-derived polioviruses in increasing frequency at multiple sites prior to detection of a poliomyelitis case

Merav Weil^*, Danit Sofer, Lester M. Shulman, Leah Weiss, Nofar Levi, Irina Aguvaev, Zvi Cohen, Klil Kestin, Rinat Vasserman, Michal Elul, Ilana S. Fratty, Neta S. Zuckerman, Oran Erster, Ruth Yishai, Lior Hecht, Sharon Alroy-Preis, Ella Mendelson, Itay Bar-Or

^*Corresponding author for this work

Ministry of Health, Israel

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Israel conducts routine environmental (15 sites) and acute flaccid paralysis (AFP) surveillance for poliovirus. During September 2021, increasing numbers of wastewater samples collected from more than one site in the Jerusalem region proved positive for ambiguous type 3 vaccine-derived poliovirus (aVDPV3), while environmental samples from remaining sampling sites were negative. In late February 2022, a VDPV3, genetically related to the Jerusalem environmental surveillance samples, was isolated from a stool sample collected from a non-immunodeficient, non-immunized child from Jerusalem who developed AFP, indicating that the aVDPV3s were circulating (cVDPV3s) rather than immunodeficiency-related VDPV3s (iVDPVs). In response to these isolations, the Israel Ministry of Health launched a catch-up immunization program.

Original language	English
Article number	161985
Journal	Science of the Total Environment
Volume	871
DOIs	https://doi.org/10.1016/j.scitotenv.2023.161985
State	Published - 1 May 2023

Funding

Funders	Funder number
Hagihon Company Ltd.
Israeli Polio National Certification Committee
Ministry of Health, State of Israel

Keywords

Acute flaccid paralysis (AFP)
Environmental surveillance
Molecular analysis
Type 3 vaccine-derived poliovirus (VDPV3)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.scitotenv.2023.161985

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Weil, M., Sofer, D., Shulman, L. M., Weiss, L., Levi, N., Aguvaev, I., Cohen, Z., Kestin, K., Vasserman, R., Elul, M., Fratty, I. S., Zuckerman, N. S., Erster, O., Yishai, R., Hecht, L., Alroy-Preis, S., Mendelson, E., & Bar-Or, I. (2023). Environmental surveillance detected type 3 vaccine-derived polioviruses in increasing frequency at multiple sites prior to detection of a poliomyelitis case. Science of the Total Environment, 871, Article 161985. https://doi.org/10.1016/j.scitotenv.2023.161985

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title = "Environmental surveillance detected type 3 vaccine-derived polioviruses in increasing frequency at multiple sites prior to detection of a poliomyelitis case",

abstract = "Israel conducts routine environmental (15 sites) and acute flaccid paralysis (AFP) surveillance for poliovirus. During September 2021, increasing numbers of wastewater samples collected from more than one site in the Jerusalem region proved positive for ambiguous type 3 vaccine-derived poliovirus (aVDPV3), while environmental samples from remaining sampling sites were negative. In late February 2022, a VDPV3, genetically related to the Jerusalem environmental surveillance samples, was isolated from a stool sample collected from a non-immunodeficient, non-immunized child from Jerusalem who developed AFP, indicating that the aVDPV3s were circulating (cVDPV3s) rather than immunodeficiency-related VDPV3s (iVDPVs). In response to these isolations, the Israel Ministry of Health launched a catch-up immunization program.",

keywords = "Acute flaccid paralysis (AFP), Environmental surveillance, Molecular analysis, Type 3 vaccine-derived poliovirus (VDPV3)",

author = "Merav Weil and Danit Sofer and Shulman, {Lester M.} and Leah Weiss and Nofar Levi and Irina Aguvaev and Zvi Cohen and Klil Kestin and Rinat Vasserman and Michal Elul and Fratty, {Ilana S.} and Zuckerman, {Neta S.} and Oran Erster and Ruth Yishai and Lior Hecht and Sharon Alroy-Preis and Ella Mendelson and Itay Bar-Or",

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doi = "10.1016/j.scitotenv.2023.161985",

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Weil, M, Sofer, D, Shulman, LM, Weiss, L, Levi, N, Aguvaev, I, Cohen, Z, Kestin, K, Vasserman, R, Elul, M, Fratty, IS, Zuckerman, NS, Erster, O, Yishai, R, Hecht, L, Alroy-Preis, S, Mendelson, E & Bar-Or, I 2023, 'Environmental surveillance detected type 3 vaccine-derived polioviruses in increasing frequency at multiple sites prior to detection of a poliomyelitis case', Science of the Total Environment, vol. 871, 161985. https://doi.org/10.1016/j.scitotenv.2023.161985

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AU - Sofer, Danit

AU - Shulman, Lester M.

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AU - Levi, Nofar

AU - Aguvaev, Irina

AU - Cohen, Zvi

AU - Kestin, Klil

AU - Vasserman, Rinat

AU - Elul, Michal

AU - Fratty, Ilana S.

AU - Zuckerman, Neta S.

AU - Erster, Oran

AU - Yishai, Ruth

AU - Hecht, Lior

AU - Alroy-Preis, Sharon

AU - Mendelson, Ella

AU - Bar-Or, Itay

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AB - Israel conducts routine environmental (15 sites) and acute flaccid paralysis (AFP) surveillance for poliovirus. During September 2021, increasing numbers of wastewater samples collected from more than one site in the Jerusalem region proved positive for ambiguous type 3 vaccine-derived poliovirus (aVDPV3), while environmental samples from remaining sampling sites were negative. In late February 2022, a VDPV3, genetically related to the Jerusalem environmental surveillance samples, was isolated from a stool sample collected from a non-immunodeficient, non-immunized child from Jerusalem who developed AFP, indicating that the aVDPV3s were circulating (cVDPV3s) rather than immunodeficiency-related VDPV3s (iVDPVs). In response to these isolations, the Israel Ministry of Health launched a catch-up immunization program.

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Environmental surveillance detected type 3 vaccine-derived polioviruses in increasing frequency at multiple sites prior to detection of a poliomyelitis case

Abstract

Funding

Keywords

UN SDGs

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