Entropic Phase Transitions with Stable Twisted Intermediates of Bio-Inspired Self-Assembly

Kai Tao, Aviad Levin, Guy Jacoby, Roy Beck, Ehud Gazit*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Controlling the hierarchical process and capturing the intermediate stage underlying bio-inspired self-assembly are pivotal for understanding their aggregation mechanism and exploring possible applications. Here, the self-assembly of a designed minimal lipopeptide was characterized, showing it to initially self-assemble to narrow nanotwists, which then ripen to wide nanotwists, and finally transit to hollow nanotubes. The supramolecular phase transitions were revealed to be driven by entropic hydrophobic interactions, rather than by the common mechanism of enthalpy-related contributions. The transformation dynamics were sufficiently slow to enable detection and characterization of each stage, thus inducing the stable and extensive distributions of twisted intermediates. The findings allow an in-depth understanding of the hierarchical self-association of bio-inspired building blocks and provide a new approach for the preparation of superstructures of unique morphologies.

Original languageEnglish
Pages (from-to)15237-15241
Number of pages5
JournalChemistry - A European Journal
Issue number43
StatePublished - 17 Oct 2016


  • entropy-driven ripening
  • lipopeptide
  • nanotubes
  • nanotwists
  • self-assembly


Dive into the research topics of 'Entropic Phase Transitions with Stable Twisted Intermediates of Bio-Inspired Self-Assembly'. Together they form a unique fingerprint.

Cite this